钯催化芳基硅氧烷与芳基卤化物的交叉偶联反应：在固相有机合成中的应用。

Palladium-catalyzed cross-coupling reactions of arylsiloxanes with aryl halides: application to solid-supported organic synthesis.

作者信息

Traficante Carla I, Delpiccolo Carina M L, Mata Ernesto G

机构信息

Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario , Suipacha 531, 2000 Rosario, Argentina.

出版信息

ACS Comb Sci. 2014 May 12;16(5):211-4. doi: 10.1021/co5000322. Epub 2014 Apr 7.

DOI:10.1021/co5000322

PMID:24689507

Abstract

The solid-phase version of the Pd-catalyzed Hiyama reaction between a variety of aryltriethoxysilanes and immobilized aryl halides was developed. Smooth cross-coupling was achieved to afford the corresponding biaryl products in moderate to excellent yields. The described protocol would be particularly useful for the construction of 4'-substituted 1,1'-biphenyl derivatives.

摘要

开发了各种芳基三乙氧基硅烷与固定化芳基卤化物之间钯催化的日向反应的固相版本。实现了顺利的交叉偶联，以中等至优异的产率得到相应的联芳基产物。所描述的方案对于构建4'-取代的1,1'-联苯衍生物将特别有用。