Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata 573-0101, Japan.
Org Lett. 2012 May 4;14(9):2286-9. doi: 10.1021/ol300670n. Epub 2012 Apr 18.
(E)-trimethyl-(3,3,3-trifluoroprop-1-enyl)silane (1) was synthesized as a reagent for use in Hiyama cross-coupling reactions for the production of β-trifluoromethylstyrene derivatives. Cross-coupling of 1 with electronically diverse aryl iodides was achieved by treatment with CsF in the presence of catalytic amounts of palladium to afford the desired products in moderate to good yields.
（E）-三甲基-（3,3,3-三氟-1-丙烯基）硅烷（1）被合成作为用于 Hiyama 交叉偶联反应的试剂，用于生产 β-三氟甲基苯乙烯衍生物。通过用氟化铯处理并在催化量的钯存在下，1 与电子不同的芳基碘化物进行交叉偶联，以中等至良好的收率得到所需的产物。
