迷迭香中二萜醌类化合物。

Manoyloxide Sesterterpenoids from Salvia mirzayanii.

机构信息

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University , G. C., Evin, Tehran, Iran.

出版信息

J Nat Prod. 2014 Apr 25;77(4):848-54. doi: 10.1021/np400948n. Epub 2014 Apr 1.

DOI:10.1021/np400948n

PMID:24689905

Abstract

Five new manoyloxide-type sesterterpenes were isolated from aerial parts of Salvia mirzayanii, a species endemic to Iran. The planar structures were established by means of 1D and 2D NMR and HRESIMS. Compounds 1-3 differed only in their configurations at C-13 and C-14. Assignment of relative and absolute configurations was achieved by NOESY experiments and by comparison of experimental and simulated ECD spectra of possible stereoisomers. The absolute configurations of 4 and 5 were established in a similar manner.

摘要

从伊朗特有物种迷迭香的地上部分分离得到五个新的曼诺内酯型倍半萜。通过 1D 和 2D NMR 和 HRESIMS 确定了其平面结构。化合物 1-3 仅在 C-13 和 C-14 处的构型不同。通过 NOESY 实验和可能的立体异构体的实验和模拟 ECD 光谱的比较，确定了相对和绝对构型。4 和 5 的绝对构型也以类似的方式确定。