来自皱叶鼠尾草根部的枞烷型和降枞烷型二萜类化合物。
Abietane and nor-abitane diterpenoids from the roots of Salvia rhytidea.
作者信息
Eghtesadi Farrokh, Moridi Farimani Mahdi, Hazeri Nourallah, Valizadeh Jafar
机构信息
Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, P.O. box 98135-674, Iran.
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.
出版信息
Springerplus. 2016 Jul 13;5(1):1068. doi: 10.1186/s40064-016-2652-0. eCollection 2016.
BACKGROUND
The genus Salvia is a rich source of structurally diverse terpenoids. Different species of the Salvia have been used in folk medicine of Iran and therefore attracted the attention of researchers for exploring their chemical constituents. In a project directed at structurally interesting bioactive metabolites from Iranian Lamiaceae, we studied Salvia rhytidea.
RESULTS
Fractionation of the petroleum ether extract of the root of S. rhytidea led to the isolation of a new 20-nor-abietane diterpenoid (1), together with seven known compounds, comprising five abietane diterpenoids (2-6), and two rearranged abietanes (7, 8). Their structures were established by a combination of 1D and 2D NMR.
CONCLUSIONS
Our results showed that the root of S. rhytidea could be considered as a new and rich source of different types of abietane and rearranged abietane diterpenoids.
背景
鼠尾草属植物富含结构多样的萜类化合物。不同种类的鼠尾草已被用于伊朗的民间医学，因此吸引了研究人员对其化学成分进行探索。在一个针对来自伊朗唇形科具有结构趣味性的生物活性代谢产物的项目中，我们研究了皱叶鼠尾草。
结果
对皱叶鼠尾草根的石油醚提取物进行分离，得到一种新的20-降-枞烷二萜（1），以及七种已知化合物，包括五种枞烷二萜（2-6）和两种重排枞烷（7, 8）。它们的结构通过一维和二维核磁共振相结合的方法确定。
结论
我们的结果表明，皱叶鼠尾草的根可被视为不同类型枞烷和重排枞烷二萜的新的丰富来源。
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