Moridi Farimani Mahdi, Miran Mansour, Nejad Ebrahimi Samad
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2019 Winter;18(1):406-411.
The genus is a valuable origin of structurally diverse terpenoids. In a project directed at structurally interesting bioactive metabolites from Iranian species, we studied Two new labdane diterpene, 6β, 14α-dihydroxy-15-acetoxysclareol (1), and 14α, 15- dihydroxy sclareol (2), were isolated from the aerial part of the plant. Their structures were established mainly by 1D and 2D NMR spectroscopic techniques, including H-H COSY, HSQC and HMBC methods and HR-ESI-TOFMS spectral data. Compound 1 and 2 were tested for their inhibitory activity toward HeLa and MCF-7 cell lines. Our results showed that is a rich source of labdane diterpenoids. These compounds are rather rare in species, although they are frequently found in other genera of the . is a new source of these diterpenoids.
该属是结构多样的萜类化合物的宝贵来源。在一个针对来自伊朗该物种的具有结构趣味性的生物活性代谢物的项目中，我们研究了……从该植物的地上部分分离出了两种新的半日花烷二萜，6β,14α - 二羟基 - 15 - 乙酰氧基香紫苏醇（1）和14α,15 - 二羟基香紫苏醇（2）。它们的结构主要通过一维和二维核磁共振光谱技术确定，包括H - H COSY、HSQC和HMBC方法以及高分辨电喷雾电离飞行时间质谱光谱数据。对化合物1和2进行了针对HeLa和MCF - 7细胞系的抑制活性测试。我们的结果表明，该植物是半日花烷二萜的丰富来源。这些化合物在该物种中相当罕见，尽管它们在该科的其他属中经常被发现。该植物是这些二萜类化合物的新来源。
