Schu Stefan, Gulve Ashish, ElDabe Sam, Baranidharan Ganesan, Wolf Katharina, Demmel Walter, Rasche Dirk, Sharma Manohar, Klase Daniel, Jahnichen Gunnar, Wahlstedt Anders, Nijhuis Harold, Liem Liong
Department of Functional Neurosurgery, University Hospital of Düsseldorf, Düsseldorf, Germany.
Pain Pract. 2015 Apr;15(4):293-9. doi: 10.1111/papr.12194. Epub 2014 Apr 1.
Spinal cord stimulation (SCS) is a standard treatment option for chronic neuropathic pain. However, some anatomical pain distributions are known to be difficult to cover with traditional SCS-induced paresthesias and/or may also induce additional, unwanted stimulation. We present the results from a retrospective review of data from patients with groin pain of various etiologies treated using neuromodulation of the dorsal root ganglion (DRG).
Data from 29 patients with neuropathic groin pain were reviewed. Patients underwent trial therapy where specifically designed leads were implanted at the target DRGs between T12 and L4. Patients who had a successful trial (> 50% improvement) received the fully implantable neuromodulation system. Pain scores were captured on a visual analog scale (VAS) at baseline and at regular follow-up visits.
Twenty-five patients (86.2%) received fully implantable neurostimulators, and the average follow-up period was 27.8 ± 4.3 (standard error of the mean, SEM) weeks. The average pain reduction was 71.4 ± 5.6%, and 82.6% (19/23) of patients experienced a > 50% reduction in their pain at the latest follow-up. Individual cases showed improvement with a variety of etiologies and pain distributions; a subanalysis of postherniorrhaphy cohort also showed significant improvement.
Early findings suggest that neuromodulation of the DRG may be an effective treatment for chronic neuropathic pain conditions in the groin region. This technique offers a useful alternative for pain conditions that do not always respond optimally to traditional SCS therapy. Neuromodulation of the DRG provided excellent cross-dermatomal paresthesia coverage, even in cases with patients with discrete pain areas. The therapy can be specific, sustained, and independent of body position.
脊髓刺激(SCS)是慢性神经性疼痛的标准治疗选择。然而,已知一些解剖学疼痛分布难以通过传统的SCS诱导的感觉异常来覆盖,和/或可能还会引发额外的不必要刺激。我们展示了对使用背根神经节(DRG)神经调节治疗各种病因引起的腹股沟疼痛患者的数据进行回顾性分析的结果。
回顾了29例神经性腹股沟疼痛患者的数据。患者接受了试验性治疗,在T12至L4之间的目标DRG处植入了专门设计的导联。试验成功(改善>50%)的患者接受了完全可植入的神经调节系统。在基线和定期随访时采用视觉模拟量表(VAS)记录疼痛评分。
25例患者(86.2%)接受了完全可植入的神经刺激器,平均随访期为27.8±4.3(均值标准误,SEM)周。平均疼痛减轻71.4±5.6%,82.6%(19/23)的患者在最近一次随访时疼痛减轻>50%。个别病例显示各种病因和疼痛分布均有改善;疝修补术后队列的亚分析也显示出显著改善。
早期研究结果表明,DRG神经调节可能是腹股沟区慢性神经性疼痛疾病的有效治疗方法。对于对传统SCS治疗反应不佳的疼痛疾病,该技术提供了一种有用的替代方法。即使在疼痛区域离散的患者中DRG神经调节也能提供良好的跨皮节感觉异常覆盖。该治疗具有特异性、持续性且与体位无关。