Hernberg Samu, Sripaiboonkij Penpatra, Quansah Reginald, Jaakkola Jouni J K, Jaakkola Maritta S
Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland; Respiratory Medicine Unit, Institute of Clinical Medicine, University of Oulu, Oulu, Finland; Respiratory Medicine Unit, Oulu University Hospital, Oulu, Finland.
Center for Environmental and Respiratory Health Research, University of Oulu, Oulu, Finland; Faculty of Public Health, Thammasat University, Thailand.
Respir Med. 2014 May;108(5):677-84. doi: 10.1016/j.rmed.2014.03.004. Epub 2014 Mar 18.
Indoor mold exposure is common worldwide and constitutes an important health problem. There are very few studies assessing the relation between mold exposure and lung function levels among non-asthmatic adults. Our objective was to assess the relations between dampness and mold exposures at home and at work and lung function. In particular, we elaborated the importance of different exposure indicators.
In a population-based study, 269 non-asthmatic adults from South Finland answered a questionnaire on indoor dampness and mold exposures at home or at work and other factors potentially influencing lung function, and performed spirometry. Multiple linear regression model was applied to study the relations between exposures and spirometric lung function levels.
In linear regression adjusting for confounding, FEV1 level was reduced on average 200 ml related to mold odor at home (effect estimate -0.20, 95% CI -0.60 to 0.21) and FVC level was reduced on average 460 ml (-0.46, -0.95 to 0.03) respectively. Exposure to mold odor at home or at work or both was related to reduced FEV1 (-0.15, -0.42 to 0.12) and FVC (-0.22, -0.55 to 0.11) levels. Women had on average 510 ml reduced FEV1 levels (-0.51, -1.0 to 0.03) and 820 ml reduced FVC levels (-0.82, -1.4 to -0.20) related to mold odor exposure at home.
Mold odor exposure was related to lower lung function levels among non-asthmatic adults, especially among women.
室内霉菌暴露在全球范围内都很常见，是一个重要的健康问题。很少有研究评估非哮喘成年人霉菌暴露与肺功能水平之间的关系。我们的目的是评估家庭和工作场所的潮湿与霉菌暴露与肺功能之间的关系。特别是，我们阐述了不同暴露指标的重要性。
在一项基于人群的研究中，来自芬兰南部的269名非哮喘成年人回答了一份关于家庭或工作场所室内潮湿和霉菌暴露以及其他可能影响肺功能的因素的问卷，并进行了肺活量测定。应用多元线性回归模型研究暴露与肺活量测定肺功能水平之间的关系。
在对混杂因素进行调整的线性回归中，在家中与霉菌气味相关的第一秒用力呼气容积（FEV1）水平平均降低200毫升（效应估计值-0.20，95%置信区间-0.60至0.21），用力肺活量（FVC）水平平均降低460毫升（-0.46，-0.95至0.03）。在家中或工作场所或两者都暴露于霉菌气味与FEV1（-0.15，-0.42至0.12）和FVC（-0.22，-0.55至0.11）水平降低有关。与在家中暴露于霉菌气味相关妇女的FEV1水平平均降低510毫升（-0.51，-1.0至0.03），FVC水平平均降低820毫升（-0.82，-1.4至-0.20）。
霉菌气味暴露与非哮喘成年人较低的肺功能水平有关，尤其是在女性中。
