Huang Chin-Wei, Hayman-Abello Brent, Hayman-Abello Susan, Derry Paul, McLachlan Richard S
Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada; Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada.
PLoS One. 2014 Apr 1;9(4):e93382. doi: 10.1371/journal.pone.0093382. eCollection 2014.
Subjective memory (SM), a self-evaluation of memory, in contrast to objective memory (OM) measured by neuropsychological testing, is less well studied in patients with epilepsy. We assessed SM before and after temporal lobectomy. The Frequency of Forgetting 10 scale (FOF-10), developed to evaluate SM in dementia, was given before and one year after temporal lobectomy. Reliability and validity for use in epilepsy were first assessed. Measures of depression (CES-D) and neuroticism (PANAS) were done before and after surgery as well as complete neuropsychological assessment of OM. Correlation analysis between FOF-10 results and all the other variables was implemented. In 48 patients the FOF-10 was reliable and valid showing high internal consistency in all items (Cronbach's alpha >0.82) and high reproducibility (p<0.01). The FOF-10 also correlated with the memory assessment clinics self rating scale (MAC-S) (p<0.01). FOF-10 scores improved or were unchanged postoperatively in 28 patients (58%) and worsened in 20 (42%). The FOF-10 did not significantly correlate with memory scores from neuropsychological testing but did correlate with perceived word finding difficulty (p<0.001) and postoperative depression (p<0.05). A reduction in number of antiepileptic drugs (AEDs) after surgery distinguished those with improved postoperative SM. No correlation was found between SM and neuroticism, side of surgery or number of seizures. The FOF-10 is a brief and reliable measure of subjective memory in patients with epilepsy. Perceived memory impairment reflects more emotional state, language problems and quantity of AEDs than actual defects in memory function. These results would potentially be useful in presurgical counselling and management of memory issues after temporal lobe surgery.
主观记忆（SM）是对记忆的自我评估，与通过神经心理学测试测量的客观记忆（OM）不同，癫痫患者对主观记忆的研究较少。我们评估了颞叶切除术前和术后的主观记忆。用于评估痴呆患者主观记忆的遗忘频率10量表（FOF-10）在颞叶切除术前和术后一年进行了测评。首先评估了该量表在癫痫患者中的信度和效度。术前和术后均进行了抑郁（CES-D）和神经质（PANAS）测量以及客观记忆的完整神经心理学评估。对FOF-10结果与所有其他变量进行了相关分析。在48例患者中，FOF-10可靠且有效，所有项目均显示出高内部一致性（Cronbach'sα>0.82）和高再现性（p<0.01）。FOF-10还与记忆评估门诊自评量表（MAC-S）相关（p<0.01）。28例患者（58%）术后FOF-10评分改善或未改变，20例（42%）恶化。FOF-10与神经心理学测试的记忆评分无显著相关性，但与感知到的找词困难（p<0.001）和术后抑郁（p<0.05）相关。术后抗癫痫药物（AEDs）数量的减少区分了术后主观记忆改善的患者。未发现主观记忆与神经质、手术侧别或癫痫发作次数之间存在相关性。FOF-10是一种简单可靠的癫痫患者主观记忆测量方法。感知到的记忆损害反映的更多是情绪状态、语言问题和AEDs的数量，而非记忆功能的实际缺陷。这些结果可能有助于颞叶手术前的咨询以及术后记忆问题的管理。
