Levendoski Elizabeth Erickson, Sundarrajan Anusha, Sivasankar M Preeti
Ann Otol Rhinol Laryngol. 2014 Jul;123(7):475-81. doi: 10.1177/0003489414527230.
Environmental humidification is a simple, cost-effective method believed to reduce superficial laryngeal drying. This study sought to validate this belief by investigating whether humidification treatment would reduce the negative effects of superficial laryngeal dehydration on phonation threshold pressure (PTP). Phonation threshold pressure data analysis may be vulnerable to bias because of lack of investigator blinding. Consequently, this study investigated the extent of PTP analysis reliability between unblinded and blinded investigators.
Healthy male and female adults were assigned to a vocal fatigue (n = 20) or control group (n = 20) based on their responses to a questionnaire. PTP was assessed after 2 hours of mouth breathing in low humidity (dehydration challenge), following a 5-minute break in ambient humidity, and after 2 hours of mouth breathing in high humidity (humidification).
PTP significantly increased following the laryngeal dehydration challenge. After humidification, PTP returned toward baseline. These effects were observed in both subject groups. PTP measurements were highly correlated between the unblinded and blinded investigator.
Humidification may be an effective approach to decrease the detrimental voice effects of superficial laryngeal dehydration. These data lay the foundation for future investigations aimed at preventing and treating the negative voice changes associated with chronic, surface laryngeal drying.
环境加湿是一种简单且经济有效的方法，人们认为它能减轻喉部表面干燥。本研究旨在通过调查加湿治疗是否能减少喉部表面脱水对发声阈压（PTP）的负面影响来验证这一观点。由于缺乏研究者盲法，发声阈压数据分析可能容易受到偏差影响。因此，本研究调查了非盲法和盲法研究者之间PTP分析可靠性的程度。
根据健康成年男女对问卷的回答，将他们分为嗓音疲劳组（n = 20）或对照组（n = 20）。在低湿度环境下张口呼吸2小时（脱水挑战）后、在环境湿度下休息5分钟后以及在高湿度环境下张口呼吸2小时（加湿）后，评估PTP。
喉部脱水挑战后PTP显著升高。加湿后，PTP恢复至基线水平。在两个受试组中均观察到这些效应。非盲法和盲法研究者的PTP测量结果高度相关。
加湿可能是减轻喉部表面脱水对嗓音有害影响的有效方法。这些数据为未来旨在预防和治疗与慢性喉部表面干燥相关的嗓音负面变化的研究奠定了基础。
