胰岛素对人肝癌细胞系PLC/PRF/5生长的影响：胰岛素受体的可能作用。
Effect of insulin on the growth of a human hepatoma cell line PLC/PRF/5: a possible role of insulin receptor.
作者信息
Motoo Y, Kobayashi K, Hattori N
机构信息
First Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa 921, Japan.
出版信息
Tohoku J Exp Med. 1988 Dec;156(4):351-7. doi: 10.1620/tjem.156.351.
Insulin produced increases in cell number, DNA synthesis and alpha-fetoprotein secretion of a human hepatoma cell line PLC/PRF/5. The insulin-treated cells showed a decrease in binding of 125I-insulin. The decreased binding was due to the decreased numbers as well as the low affinity constant of insulin receptor. These data suggest that insulin is a growth factor for the human hepatoma cells and that insulin receptor plays a role in the growth-promoting effect of insulin.
所产生的胰岛素可增加人肝癌细胞系PLC/PRF/5的细胞数量、DNA合成及甲胎蛋白分泌。经胰岛素处理的细胞显示125I胰岛素结合减少。结合减少是由于胰岛素受体数量减少以及亲和力常数降低所致。这些数据表明胰岛素是人类肝癌细胞的生长因子，且胰岛素受体在胰岛素的促生长作用中发挥作用。
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