趋化因子作为儿科肾脏疾病的潜在标志物。
Chemokines as potential markers in pediatric renal diseases.
机构信息
Unidade de Nefrologia Pediátrica, Departamento de Pediatria, Universidade Federal de Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, Brazil ; Instituto Nacional de Ciência e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, UFMG, 30130-100 Belo Horizonte, MG, Brazil ; Laboratório Interdisciplinar de Investigação Médica Faculdade de Medicina, UFMG, Avenida Alfredo Balena 190, 2nd Floor, Room No.281, 30130-100 Belo Horizonte, MG, Brazil.
Instituto Nacional de Ciência e Tecnologia em Medicina Molecular (INCT-MM), Faculdade de Medicina, UFMG, 30130-100 Belo Horizonte, MG, Brazil ; Laboratório Interdisciplinar de Investigação Médica Faculdade de Medicina, UFMG, Avenida Alfredo Balena 190, 2nd Floor, Room No.281, 30130-100 Belo Horizonte, MG, Brazil ; Departamento de Nefrologia, Santa Casa de Misericordia de Belo Horizonte, 30130-100 Belo Horizonte, MG, Brazil.
出版信息
Dis Markers. 2014;2014:278715. doi: 10.1155/2014/278715. Epub 2014 Feb 17.
Glomerular diseases and obstructive uropathies are the two most frequent causes of chronic kidney disease (CKD) in children. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric renal diseases. Among several putative biomarkers, chemokines emerge as promising molecules since they play relevant roles in the pathophysiology of pediatric renal diseases. The evaluation of these inflammatory mediators might help in the management of diverse renal diseases in children and the detection of patients at high risk to develop CKD. The aim of this paper is to revise general aspects of chemokines and the potential link between chemokines and the most common pediatric renal diseases by including experimental and clinical evidence.
肾小球疾病和尿路梗阻性疾病是儿童慢性肾脏病（CKD）的两个最常见原因。最近，生物标志物已成为临床研究的焦点，作为儿科肾脏疾病潜在有用的诊断工具。在几种假定的生物标志物中，趋化因子作为有前途的分子出现，因为它们在儿科肾脏疾病的病理生理学中发挥相关作用。这些炎症介质的评估可能有助于儿童多种肾脏疾病的治疗，并检测发生 CKD 的高危患者。本文的目的是通过纳入实验和临床证据，复习趋化因子的一般方面以及趋化因子与最常见的儿科肾脏疾病之间的潜在联系。
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