Tavana Zohreh, Hosseinmirzaei Sara
Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Iran Red Crescent Med J. 2013 Dec;15(12):e10394. doi: 10.5812/ircmj.10394. Epub 2013 Dec 5.
Preeclampsia is a pregnancy multisystem disorder of unknown etiology. It is a significant cause of maternal and fetal morbidity and mortality.
Due to the significant role of magnesium in physiological regulation of blood pressure, this study was conducted to measure the level of magnesium in pre-eclampsia and control groups since the beginning of the pregnancy.
We enrolled 500 pregnant women with gestational age of 18-22 weeks who had referred to the Section of Obstetrics and Gynecology of Hafez hospital of Shiraz. Initially, blood samples were obtained from all subjects. 26 cases with diagnosis of preeclampsia were detected at the next referral. For each case, two normal pregnant women, at the same gestational age, were considered as the control group. The second blood samples were obtained from all the cases and controls. All of the samples were sent to check the level of magnesium. The data was analyzed with the SPSS and Student's t-test.
The initial level of magnesium in pre-eclampsia women was not only significantly less than the control group (1.81 ± 0.25 mg/dl vs. 2.3 ± 0.44 mg/dl, P < 0.001), but also the secondary level was low, when the diagnosis was confirmed (1.72 ± 0.38 mg/dl vs. 2.2 ± 0.63 mg/dl, P < 0.05).
We found a gradual decrease in mean serum magnesium level with increasing period of gestation in the pre-eclampsia women. This implicates that the level of magnesium in preeclampsia was lower than the control group since the beginning of pregnancy. According to our results, checking the level of magnesium should be considered as the predicting factor of preeclampsia during the first evaluation of pregnancy.
子痫前期是一种病因不明的妊娠多系统疾病。它是孕产妇和胎儿发病及死亡的重要原因。
由于镁在血压生理调节中具有重要作用，本研究旨在自妊娠开始起测量子痫前期组和对照组的镁水平。
我们纳入了500名孕周为18 - 22周、转诊至设拉子哈菲兹医院妇产科的孕妇。最初，从所有受试者采集血样。在下一次转诊时检测出26例子痫前期病例。对于每例病例，选取两名相同孕周的正常孕妇作为对照组。从所有病例和对照组采集第二份血样。所有样本均送去检测镁水平。数据采用SPSS软件和学生t检验进行分析。
子痫前期女性的初始镁水平不仅显著低于对照组（1.81±0.25毫克/分升对2.3±0.44毫克/分升，P<0.001），而且在确诊时的二次检测水平也较低（1.72±0.38毫克/分升对2.2±0.63毫克/分升，P<0.05）。
我们发现子痫前期女性的平均血清镁水平随着孕周增加而逐渐降低。这意味着子痫前期患者自妊娠开始镁水平就低于对照组。根据我们的结果，在首次孕期评估时，检测镁水平应被视为子痫前期的预测因素。
