Department of Biochemistry, Government Medical College, Srikakulam, Andhra Pradesh, 532001, India.
Department of Biochemistry, Andhra Medical College, Visakhapatnam, Andhra Pradesh, 530002, India.
Biol Trace Elem Res. 2024 Oct;202(10):4410-4417. doi: 10.1007/s12011-023-04030-2. Epub 2023 Dec 30.
Pre-eclampsia, a hypertensive disorder occurring during pregnancy, poses significant risks to maternal and fetal health worldwide. Despite extensive research, the precise cause of pre-eclampsia remains unknown. Recent studies have indicated that trace elements, essential minerals crucial for various biological processes, might be significant factors in the development of pre-eclampsia. This study examines the intricate relationship between trace elements (magnesium, copper, zinc, calcium, phosphorus, and iron) and the severity of pre-eclampsia. The study involves a total of 150 participants, categorized into three distinct groups: 50 individuals with mild pre-eclampsia, 50 with severe pre-eclampsia, and 50 healthy pregnant controls. Specifically, out of the 100 pre-eclampsia cases, 5 were identified as early-onset and 95 as late-onset. Participants were recruited from a tertiary care hospital based on stringent inclusion and exclusion criteria. All the trace elements were quantitatively measured by direct colorimetric method using the Beckman Coulter AU480 analyzer system (Beckman Coulter, USA). Pre-eclampsia cases exhibited a significantly lowered level of magnesium (2.02 mg/dL), zinc (57.62 mg/dL), calcium (8.02 mg/dL), and phosphorus (3.93 mg/dL). These levels were approximately 14.4%, 20.2%, 21.1%, and 22.6% lower when compared to healthy pregnant women. Conversely, copper (151.67 mg/dL) and iron (53 μg/dL) levels were significantly elevated in pre-eclampsia cases. Age emerged as a significant risk factor, correlating with heightened pre-eclampsia susceptibility. Magnesium showed a protective effect, correlating negatively with age and positively with gestational age. The complex relationships between trace elements, age, and pre-eclampsia underline the need for personalized interventions, potentially including magnesium supplementation, in high-risk pregnancies.
子痫前期是一种妊娠期间发生的高血压疾病，对全球母婴健康构成重大威胁。尽管进行了广泛的研究，但子痫前期的确切病因仍不清楚。最近的研究表明，微量元素是各种生物过程所必需的关键矿物质，可能是子痫前期发展的重要因素。本研究探讨了微量元素（镁、铜、锌、钙、磷和铁）与子痫前期严重程度之间的复杂关系。该研究共纳入 150 名参与者，分为三组：50 名轻度子痫前期患者、50 名重度子痫前期患者和 50 名健康孕妇对照组。具体而言，100 例子痫前期患者中，5 例为早发型，95 例为晚发型。参与者是根据严格的纳入和排除标准从一家三级保健医院招募的。所有微量元素均采用贝克曼库尔特 AU480 分析仪系统（贝克曼库尔特，美国）的直接比色法进行定量测量。子痫前期患者的镁（2.02mg/dL）、锌（57.62mg/dL）、钙（8.02mg/dL）和磷（3.93mg/dL）水平显著降低。与健康孕妇相比，这些水平分别低约 14.4%、20.2%、21.1%和 22.6%。相反，子痫前期患者的铜（151.67mg/dL）和铁（53μg/dL）水平显著升高。年龄是一个显著的危险因素，与子痫前期易感性增加相关。镁具有保护作用，与年龄呈负相关，与胎龄呈正相关。微量元素、年龄与子痫前期之间的复杂关系强调了需要针对高危妊娠进行个性化干预，包括可能的镁补充。
