Kao G F, Sulica V I
Department of Pathology, Georgetown University Medical School, Washington, D.C.
Am J Dermatopathol. 1989 Apr;11(2):172-6. doi: 10.1097/00000372-198911020-00010.
Focal acantholytic dyskeratosis (FAD) is a distinctive histologic pattern characterized by suprabasilar clefts surrounding dermal papillae (villi), acantholytic and dyskeratotic cells at all levels of the epidermis, hyperkeratosis, and parakeratosis. The features of FAD are typically seen in Darier's disease, warty dyskeratoma, and transient acantholytic dermatosis; they are also present in a variety of cutaneous neoplastic and nonneoplastic lesions. FAD, however, has not been previously described in lesions of inflammatory dermatoses. We report a case of FAD occurring in lesions of pityriasis rubra pilaris (PRP). To the best of our knowledge, this is the first reported case of this kind. We also review the pertinent literature.
局灶性棘层松解性角化不良（FAD）是一种独特的组织学模式，其特征为围绕真皮乳头（绒毛）的基底层上裂隙、表皮各层的棘层松解和角化不良细胞、角化过度和不全角化。FAD的特征通常见于 Darier病、疣状角化不良瘤和暂时性棘层松解性皮病；它们也存在于各种皮肤肿瘤性和非肿瘤性病变中。然而，FAD此前尚未在炎症性皮肤病的病变中被描述过。我们报告1例发生在红皮病型毛发红糠疹（PRP）病变中的FAD。据我们所知，这是首例此类报道病例。我们还复习了相关文献。
