放线菌酮对大鼠肝脏细胞核内高迁移率族蛋白水平的影响。
Effect of cycloheximide on the levels of nuclear HMG proteins in rat liver.
作者信息
Oka T, Han J P, Natori Y
机构信息
Department of Nutritional Chemistry, School of Medicine, University of Tokushima, Japan.
出版信息
Biochem Int. 1988 Dec;17(6):1151-5.
PMID:2469423
Abstract
Within 30 minutes of administration of cycloheximide to rats, rRNA synthesis in isolated liver nuclei was inhibited by approximately 50%. The nuclear contents of high mobility group (HMG) proteins, including HMG 1, 2 and 14, were found to be decreased in parallel with the inhibition of RNA synthesis while the contents of the total cellular HMG proteins remained unchanged. The role of HMG proteins in the regulation of RNA synthesis is discussed.
摘要
给大鼠注射放线菌酮后30分钟内，分离的肝细胞核中的rRNA合成被抑制了约50%。发现包括HMG 1、2和14在内的高迁移率族（HMG）蛋白的核含量与RNA合成的抑制同时下降，而细胞总HMG蛋白的含量保持不变。本文讨论了HMG蛋白在RNA合成调控中的作用。
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