乙型和丙型肝炎病毒感染是胆管癌发生的一个危险因素。
Hepatitis B and C virus infection is a risk factor for the development of cholangiocarcinoma.
作者信息
Matsumoto Kazuya, Onoyama Takumi, Kawata Soichiro, Takeda Yohei, Harada Kenichi, Ikebuchi Yuichiro, Ueki Masaru, Miura Norimasa, Yashima Kazuo, Koda Masahiko, Sakamoto Teruhisa, Endo Masanori, Horie Yasushi, Murawaki Yoshikazu
机构信息
Department of Gastroenterology, Tottori University Hospital, Japan.
出版信息
Intern Med. 2014;53(7):651-4. doi: 10.2169/internalmedicine.53.1410. Epub 2012 Mar 1.
OBJECTIVE
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection may be involved in the development of cholangiocarcinoma. The prevalence of HBV and HCV infection was examined in patients with intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC).
METHODS
The levels of HBV surface antigens (HBsAg), antibodies against HBV core antigens (HBcAb) and hepatitis C virus antibodies (HCV-Ab) were determined in sera obtained from 145 consecutive patients (50 patients with ICC, 95 patients with ECC).
RESULTS
The seroprevalence of HBsAg was 10% in the ICC patients and 4.2% in the ECC patients. The prevalence of HCV-Ab was 20% in the ICC patients and 7.4% in the ECC patients.
CONCLUSION
The prevalence of HBsAg and HCV-Ab is 0.8-2.2% and 1-2%, respectively, in the Japanese population living in the Tottori area. Furthermore, HBV and HCV infection is a possible risk factor for the development of cholangiocarcinoma. Therefore, the surveillance of ICC and ECC is needed in HBV and HCV carriers.
目的
慢性乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染可能与胆管癌的发生有关。本研究检测了肝内胆管癌（ICC）和肝外胆管癌（ECC）患者中HBV和HCV感染的流行情况。
方法
对145例连续患者（50例ICC患者，95例ECC患者）的血清进行检测，测定HBV表面抗原（HBsAg）、抗HBV核心抗原抗体（HBcAb）和丙型肝炎病毒抗体（HCV-Ab）水平。
结果
ICC患者中HBsAg的血清流行率为10%，ECC患者中为4.2%。ICC患者中HCV-Ab的流行率为20%，ECC患者中为7.4%。
结论
居住在鸟取地区的日本人群中，HBsAg和HCV-Ab的流行率分别为0.8%-2.2%和1%-2%。此外，HBV和HCV感染是胆管癌发生的一个可能危险因素。因此，需要对HBV和HCV携带者进行ICC和ECC监测。
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