韩国乙型肝炎病毒感染与肝内胆管癌：一项病例对照研究。

Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: a case-control study.

作者信息

Lee Tae Y, Lee Sang S, Jung Seok W, Jeon Seong H, Yun Sung-Cheol, Oh Hyoung-Chul, Kwon Seunghyun, Lee Sung K, Seo Dong W, Kim Myung-Hwan, Suh Dong J

机构信息

Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

出版信息

Am J Gastroenterol. 2008 Jul;103(7):1716-20. doi: 10.1111/j.1572-0241.2008.01796.x. Epub 2008 Jun 28.

DOI:10.1111/j.1572-0241.2008.01796.x

PMID:18557716

Abstract

OBJECTIVES

There is a wide variation in risk factors for intrahepatic cholangiocarcinoma (ICC) among various populations. Several studies have suggested that hepatitis C virus (HCV) infection may play a role in the development of ICC, whereas the role of hepatitis B virus (HBV) infection is less clear.

METHODS

To determine whether HBV or HCV infection is a risk factor of ICC, we compared baseline demographic and clinical factors in 622 patients diagnosed between 2000 and 2004 with histologically confirmed ICC and 2,488 healthy controls, matched 4:1 with ICC patients for sex and year of birth.

RESULTS

HBV infection (odds ratio [OR] 2.3, 95% confidence interval [CI] 1.6-3.3), but not HCV infection, was significantly related to ICC. Other significant risk factors for ICC included liver cirrhosis (OR 13.6), heavy alcohol consumption (OR 6.6), diabetes (OR 3.2), Clonorchis sinensis infection (OR 13.6), hepatolithiasis (OR 50.0), and choledochal cysts (OR 10.7).

CONCLUSIONS

Our results indicate that development of ICC seems to be more closely related to HBV infection than to HCV infection in Korea, where both HBV and ICC are endemic.

摘要

目的

不同人群中肝内胆管癌（ICC）的危险因素差异很大。多项研究表明，丙型肝炎病毒（HCV）感染可能在ICC的发生中起作用，而乙型肝炎病毒（HBV）感染的作用尚不清楚。

方法

为了确定HBV或HCV感染是否为ICC的危险因素，我们比较了2000年至2004年间确诊的622例经组织学证实的ICC患者与2488例健康对照者的基线人口统计学和临床因素，健康对照者与ICC患者按性别和出生年份以4:1进行匹配。

结果

与ICC显著相关的是HBV感染（比值比[OR]2.3，95%置信区间[CI]1.6 - 3.3），而非HCV感染。ICC的其他显著危险因素包括肝硬化（OR 13.6）、大量饮酒（OR 6.6）、糖尿病（OR 3.2）、华支睾吸虫感染（OR 13.6）、肝内胆管结石（OR 50.0）和胆总管囊肿（OR 10.7）。