Collison Frederick T, Fishman Gerald A, McAnany J Jason, Zernant Jana, Allikmets Rando
*Pangere Center for Hereditary Retinal Diseases, The Chicago Lighthouse for People Who Are Blind or Visually Impaired, Chicago, Illinois; †Department of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois; and Departments of ‡Ophthalmology, and §Pathology and Cell Biology, Columbia University, New York, New York.
Retina. 2014 Sep;34(9):1888-95. doi: 10.1097/IAE.0000000000000144.
To investigate psychophysical thresholds in Stargardt disease with the full-field stimulus test (FST).
Visual acuity, spectral domain optical coherence tomography, full-field electroretinogram, and FST measurements were made in 1 eye of 24 patients with Stargardt disease. Dark-adapted rod FST thresholds were measured with short-wavelength stimuli, and cone FST thresholds were obtained from the cone plateau phase of dark adaptation using long-wavelength stimuli. Correlation coefficients were calculated for FST thresholds versus macular thickness, visual acuity, and electroretinogram amplitudes.
The Stargardt disease patients' FST cone thresholds correlated significantly with visual acuity, macular thickness, and electroretinogram cone response amplitudes (all P < 0.01). The patients' FST rod thresholds correlated with electroretinogram rod response amplitudes (P < 0.01) but not macular thickness (P = 0.05). All patients with Stargardt disease with flecks confined to the macula, and most of the patients with flecks extending outside of the macula had normal FST thresholds. All patients with extramacular atrophic changes had elevated FST cone thresholds and most had elevated FST rod thresholds.
Full-field stimulus test rod and cone threshold elevation in patients with Stargardt disease correlated well with measures of structure and function, as well as ophthalmoscopic retinal appearance. The Full-field stimulus test appears to be a useful tool for assessing rod and cone function in Stargardt disease.
通过全视野刺激试验（FST）研究斯塔加特病的心理物理学阈值。
对24例斯塔加特病患者的1只眼睛进行视力、光谱域光学相干断层扫描、全视野视网膜电图和FST测量。使用短波长刺激测量暗适应视杆细胞FST阈值，使用长波长刺激从暗适应的视锥细胞平台期获得视锥细胞FST阈值。计算FST阈值与黄斑厚度、视力和视网膜电图振幅的相关系数。
斯塔加特病患者的FST视锥细胞阈值与视力、黄斑厚度和视网膜电图视锥细胞反应振幅显著相关（均P<0.01）。患者的FST视杆细胞阈值与视网膜电图视杆细胞反应振幅相关（P<0.01），但与黄斑厚度无关（P=0.05）。所有黄斑区仅有斑点的斯塔加特病患者，以及大多数斑点延伸至黄斑区以外的患者，FST阈值均正常。所有黄斑外萎缩性改变的患者FST视锥细胞阈值升高，大多数患者FST视杆细胞阈值升高。
斯塔加特病患者的全视野刺激试验视杆细胞和视锥细胞阈值升高与结构和功能测量以及检眼镜下视网膜外观密切相关。全视野刺激试验似乎是评估斯塔加特病视杆细胞和视锥细胞功能的有用工具。
