Inhibition of HIV replication in cell culture by the specific aspartic protease inhibitor pepstatin A.
作者信息
von der Helm K, Gürtler L, Eberle J, Deinhardt F
机构信息
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig-Maximilians University of Munich, FRG.
出版信息
FEBS Lett. 1989 Apr 24;247(2):349-52. doi: 10.1016/0014-5793(89)81368-7.
PMID:2469601
Abstract
After incubation of H9 cells infected with human immunodeficiency virus (HIV) with pepstatin A at 10(-4) M for 2, 4, or 11 days, the culture medium contained significantly less HIV core antigen (p24) than controls without pepstatin A and no or only borderline activity of reverse transcriptase was detected. In addition, after pepstatin A treatment no infectious HIV at 2 or 4 days and only minimal amounts at 11 days were detectable in the culture medium.
摘要
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