Parvini Maryam, Satarian Leila, Parivar Kazem, Javan Mohammad, Tondar Mahdi, Ahmad Sajjad, Baharvand Hossein
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Mol Neurobiol. 2014 Oct;50(2):597-612. doi: 10.1007/s12035-014-8684-y. Epub 2014 Apr 3.
The generation of retinal pigment epithelial (RPE) cells from pluripotent stem cells is a topic of interest over the past few years as dysfunctional RPE cells are a primary cause of ocular diseases. However, a number of obstacles need to be overcome before these cells can be used in clinical trials. This review aims to provide an overview of the latest reports on the generation of RPE cells from human pluripotent stem cells. Challenges that need to be addressed in future studies for their therapeutic applications are discussed. Proposed research goals for this fast growing field are highlighted.
在过去几年中，多能干细胞生成视网膜色素上皮（RPE）细胞一直是一个备受关注的话题，因为功能失调的RPE细胞是眼部疾病的主要原因。然而，在这些细胞能够用于临床试验之前，还需要克服许多障碍。本综述旨在概述关于从人类多能干细胞生成RPE细胞的最新报告。讨论了在未来研究中其治疗应用需要解决的挑战。强调了这个快速发展领域的拟议研究目标。
