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植物病程相关蛋白家族过敏原的当前概述。

Current overview of allergens of plant pathogenesis related protein families.

作者信息

Sinha Mau, Singh Rashmi Prabha, Kushwaha Gajraj Singh, Iqbal Naseer, Singh Avinash, Kaushik Sanket, Kaur Punit, Sharma Sujata, Singh Tej P

机构信息

Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

出版信息

ScientificWorldJournal. 2014 Feb 16;2014:543195. doi: 10.1155/2014/543195. eCollection 2014.

DOI:10.1155/2014/543195
PMID:24696647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3947804/
Abstract

Pathogenesis related (PR) proteins are one of the major sources of plant derived allergens. These proteins are induced by the plants as a defense response system in stress conditions like microbial and insect infections, wounding, exposure to harsh chemicals, and atmospheric conditions. However, some plant tissues that are more exposed to environmental conditions like UV irradiation and insect or fungal attacks express these proteins constitutively. These proteins are mostly resistant to proteases and most of them show considerable stability at low pH. Many of these plant pathogenesis related proteins are found to act as food allergens, latex allergens, and pollen allergens. Proteins having similar amino acid sequences among the members of PR proteins may be responsible for cross-reactivity among allergens from diverse plants. This review analyzes the different pathogenesis related protein families that have been reported as allergens. Proteins of these families have been characterized in regard to their biological functions, amino acid sequence, and cross-reactivity. The three-dimensional structures of some of these allergens have also been evaluated to elucidate the antigenic determinants of these molecules and to explain the cross-reactivity among the various allergens.

摘要

病程相关（PR）蛋白是植物源性过敏原的主要来源之一。这些蛋白由植物在诸如微生物和昆虫感染、创伤、暴露于刺激性化学物质以及大气条件等应激条件下作为防御反应系统诱导产生。然而，一些更易暴露于紫外线照射、昆虫或真菌攻击等环境条件下的植物组织会组成型表达这些蛋白。这些蛋白大多对蛋白酶具有抗性，并且它们中的大多数在低pH值下表现出相当的稳定性。已发现许多这类植物病程相关蛋白可作为食物过敏原、乳胶过敏原和花粉过敏原。PR蛋白成员之间具有相似氨基酸序列的蛋白可能是导致不同植物过敏原之间交叉反应的原因。本综述分析了已被报道为过敏原的不同病程相关蛋白家族。这些家族的蛋白已在生物学功能、氨基酸序列和交叉反应性方面进行了表征。还评估了其中一些过敏原的三维结构，以阐明这些分子的抗原决定簇，并解释各种过敏原之间的交叉反应性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ea7/3947804/9a95cdf5719a/TSWJ2014-543195.014.jpg
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