Ebner C, Hoffmann-Sommergruber K, Breiteneder H
Institute of Pathophysiology, University of Vienna, Vienna, Austria.
Allergy. 2001;56 Suppl 67:43-4. doi: 10.1034/j.1398-9995.2001.00913.x.
In general, pathogenesis-related (PR) proteins are expressed by plants in response to stress conditions like infection, exposure to certain chemicals, wounding and environmental conditions. In some plant tissues, however, PR proteins are constitutively expressed, e.g. in pollens or fruits, tissues that are more likely to be attacked (by insects or fungi) or exposed to atmospheric conditions (e.g. UV irradiation). PR proteins display multiple effects within the plant and possess antimicrobial activity, and can thus be regarded as a part of the plant's defense system. Analyzing known amino acid sequences and functions of characterized (cloned) food allergens, it is remarkable that many of these molecules can be classified as PR proteins. Many PR proteins are stable at low pH, and display considerable resistance to proteases, requirements to act as food allergens. According to sequence characteristics and their enzymatic or biologic activity, PR proteins can be divided into 14 groups. Seven of these 14 groups contain proteins with allergenic properties, six groups contain food allergens.
一般来说，病程相关（PR）蛋白是植物在应对感染、接触某些化学物质、受伤和环境条件等应激状况时表达的。然而，在一些植物组织中，PR蛋白是组成型表达的，例如在花粉或果实中，这些组织更容易受到（昆虫或真菌的）攻击或暴露于大气条件下（如紫外线照射）。PR蛋白在植物体内发挥多种作用并具有抗菌活性，因此可被视为植物防御系统的一部分。分析已知的氨基酸序列以及已鉴定（克隆）的食物过敏原的功能后发现，值得注意的是，这些分子中的许多都可归类为PR蛋白。许多PR蛋白在低pH值下稳定，并且对蛋白酶具有相当的抗性，这是作为食物过敏原的必要条件。根据序列特征及其酶活性或生物学活性，PR蛋白可分为14组。这14组中的7组含有具有致敏特性的蛋白，6组含有食物过敏原。
