Ni Jing, Qiu Li-Juan, Zhang Min, Wen Peng-Fei, Ye Xiao-Ran, Liang Yan, Pan Hai-Feng, Ye Dong-Qing
Department of Epidemiology and Biostatistics, School of Public Health and.
Endocr Res. 2014;39(4):180-8. doi: 10.3109/07435800.2013.879167. Epub 2014 Apr 3.
To determine whether the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) CT60 polymorphism (rs3087243) confers susceptibility to autoimmune thyroid disease (AITDs).
A meta-analysis was performed using: (1) allelic contrast, (2) recessive model and (3) dominant model. Electronic search of PubMed, Medline and Chinese National Knowledge Infrastructure (CNKI) was conducted to select studies.
Finally, a total of 20 separate studies were available for the current meta-analysis: Graves' disease (GD): 18 studies including 1 Iranian, 6 Caucasian and 11 Asian populations; Hashimoto's thyroiditis (HT): seven studies including one Iranian, three Caucasian and three Asian populations. A significant association was found between the CTLA-4 CT60 polymorphism (rs3087243) and GD, with regard to comparisons between allele and genotype frequencies (all p < 0.001). After stratification by ethnicity, significant relationships were consistently identified both in Caucasian and Asian populations. Furthermore, the association between this allelic variant and HT risk was also found in overall and Asian populations (OR: 1.26, 95% CI: 1.10-1.44; OR: 1.45, 95% CI: 1.19-1.76, respectively).
Taken together, our study suggested that the CT60 polymorphism (rs3087243) in CTLA-4 gene might confer susceptibility to the AITDs (GD/HT).
确定细胞毒性T淋巴细胞相关抗原4（CTLA-4）CT60多态性（rs3087243）是否与自身免疫性甲状腺疾病（AITD）易感性相关。
采用以下方法进行荟萃分析：（1）等位基因对比，（2）隐性模型和（3）显性模型。通过电子检索PubMed、Medline和中国知网（CNKI）来选择研究。
最终，共有20项独立研究可用于当前的荟萃分析：格雷夫斯病（GD）：18项研究，包括1个伊朗人群、6个白种人群和11个亚洲人群；桥本甲状腺炎（HT）：7项研究，包括1个伊朗人群、3个白种人群和3个亚洲人群。CTLA-4 CT60多态性（rs3087243）与GD之间在等位基因和基因型频率比较方面存在显著关联（所有p<0.001）。按种族分层后，在白种人和亚洲人群中均一致发现显著关系。此外，在总体人群和亚洲人群中也发现了该等位基因变异与HT风险之间的关联（OR分别为：1.26，95%CI：1.10-1.44；OR：1.45，95%CI：1.19-1.76）。
综上所述，我们的研究表明CTLA-4基因中的CT60多态性（rs3087243）可能与AITD（GD/HT）易感性相关。
