Lee H-H, Chu C-Y, Su H-M, Lin T-H, Voon W-C, Lai W-T, Sheu S-H, Hsu P-C
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital.
Diabet Med. 2014 Jul;31(7):e25-8. doi: 10.1111/dme.12458.
Purulent pericarditis is an acute and fulminant disease characterized by pus accumulation in the pericardial space. Its incidence has declined substantially and the common pathogen has changed since the beginning of the antibiotic era; however, it is still found in some patients with immunocompromised conditions.
We report a rare case in which the onset of diabetes mellitus presented as extremely high HbA1c concentration, ketoacidosis, multi-site abscesses and purulent pericarditis. After antibiotic therapy and pericardiocentesis, the purulent pericarditis still did not resolve and further intrapericardial thrombolytic therapy also failed. Finally, this patient was treated successfully by surgical debridement and pericardiectomy.
In the immunocompromised state of severe hyperglycaemia, purulent pericarditis is a possible complication of uncontrolled infection. If purulent pericarditis cannot be cured using non-surgical treatments, such as antibiotic therapy, pericardiocentesis and intrapericardial thrombolytic therapy, a surgical pericardiectomy should be considered to avoid morbidity and mortality.
化脓性心包炎是一种急性暴发性疾病,其特征为心包腔内积脓。自抗生素时代开始以来,其发病率已大幅下降,常见病原体也发生了变化;然而,在一些免疫功能低下的患者中仍可发现。
我们报告一例罕见病例,糖尿病起病表现为糖化血红蛋白浓度极高、酮症酸中毒、多部位脓肿和化脓性心包炎。经抗生素治疗和心包穿刺术后,化脓性心包炎仍未缓解,心包内溶栓治疗也失败。最后,该患者通过手术清创和心包切除术成功治愈。
在严重高血糖的免疫功能低下状态下,化脓性心包炎是感染控制不佳的一种可能并发症。如果使用抗生素治疗、心包穿刺术和心包内溶栓治疗等非手术治疗方法无法治愈化脓性心包炎,则应考虑进行手术心包切除术,以避免发病和死亡。