Department of Veterinary Preventive Medicine, The Ohio State University, Columbus, OH, USA; Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH, USA.
Influenza Other Respir Viruses. 2014 Jul;8(4):493-8. doi: 10.1111/irv.12250. Epub 2014 Apr 2.
The accurate and timely characterization of influenza A viruses (IAV) from natural reservoirs is essential for responses to animal and public health threats. Differences between antigenic and genetic subtyping results for 161 IAV isolates recovered from migratory birds in the central United States during 2010-2011 delayed the recognition of four isolates of interest. Genomic sequencing identified the first reported Eurasian-origin H10 subtype in North America and three additional H14 isolates showing divergence from previously reported H14 isolates. Genomic analyses revealed additional diversity among IAV isolates not detected by antigenic subtyping and provided further insight into interhemispheric spread of avian-origin IAVs.
准确、及时地描述来自自然宿主的甲型流感病毒（IAV）对于应对动物和公共卫生威胁至关重要。2010 年至 2011 年期间，在美国中部迁徙鸟类中分离出的 161 株 IAV 分离株的抗原和遗传亚型分型结果存在差异，这导致对 4 株具有重要意义的分离株的识别出现了延迟。基因组测序鉴定了在北美首次报告的欧亚起源的 H10 亚型以及另外 3 株与先前报告的 H14 分离株有差异的 H14 分离株。基因组分析揭示了通过抗原亚型鉴定未检测到的 IAV 分离株的更多多样性，并进一步深入了解了源自禽类的 IAV 在两个半球之间的传播。
