Sharma Aman, Reddy Mallapu Hithesh, Sharma Kusum, Dogra Sunil, Vijayvergiya Rajesh
Rheumatology Wing, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Int J Rheum Dis. 2016 Mar;19(3):300-4. doi: 10.1111/1756-185X.12336. Epub 2014 Apr 4.
To study endothelial dysfunction in patients with psoriatic arthritis (PsA) without risk factors for cardiovascular disease.
Forty patients with PsA according to Classification Criteria for Psoriatic Arthritis (CASPAR) criteria and forty age- and sex-matched controls were included. Patients with risk factors for cardiovascular disease were excluded. Endothelial function was assessed by measuring endothelial-dependent flow-mediated vasodilatation (FMD%) and endothelial-independent nitroglycerin-mediated dilatation (NMD%) in the brachial artery.
There was a significant impairment of FMD% in patients as compared to controls (mean 8.3% vs. 10.8%, P = 0.007), but there was no significant difference in NMD%.
There is presence of endothelial dysfunction in patients with PsA independent of risk factors for cardiovascular disease.
研究无心血管疾病危险因素的银屑病关节炎（PsA）患者的内皮功能障碍。
纳入40例符合银屑病关节炎分类标准（CASPAR标准）的PsA患者以及40例年龄和性别匹配的对照。排除有心血管疾病危险因素的患者。通过测量肱动脉内皮依赖性血流介导的血管舒张（FMD%）和内皮非依赖性硝酸甘油介导的舒张（NMD%）来评估内皮功能。
与对照组相比，患者的FMD%有显著损害（平均8.3%对10.8%，P = 0.007），但NMD%无显著差异。
PsA患者存在独立于心血管疾病危险因素的内皮功能障碍。
