Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition. 2014 May;30(5):503-10. doi: 10.1016/j.nut.2013.08.014.
The aim of this study was to review the current corpus of human studies to determine the association of various doses and durations of fructose consumption on metabolic syndrome.
We searched human studies in PubMed, Scopus, Ovid, ISI Web of Science, Cochrane library, and Google Scholar databases. We searched for the following keywords in each paper: metabolic syndrome x, insulin resistance, blood glucose, blood sugar, fasting blood sugar, triglycerides, lipoproteins, HDL, cholesterol, LDL, blood pressure, mean arterial pressure, systolic blood pressure, diastolic blood pressure, hypertens*, waist circumference, and fructose, sucrose, high-fructose corn syrup, or sugar.
Overall, 3102 articles were gathered. We excluded studies on natural fructose content of foods, non-clinical trials, and trials in which fructose was recommended exclusively as sucrose or high-fructose corn syrup. Overall, 3069 articles were excluded. After review by independent reviewers, 15 studies were included in the meta-analysis. Fructose consumption was positively associated with increased fasting blood sugar (FBS; summary mean difference, 0.307; 95% confidence interval [CI], 0.149-0.465; P = 0.002), elevated triglycerides (TG; 0.275; 95% CI, 0.014-0.408; P = 0.002); and elevated systolic blood pressure (SBP; 0.297; 95% CI, 0.144-0.451; P = 0.002). The corresponding figure was inverse for high-density lipoprotein (HDL) cholesterol (-0.267; 95% CI, -0.406 to -0.128; P = 0.001). Significant heterogeneity existed between studies, except for FBS. After excluding studies that led to the highest effect on the heterogeneity test, the association between fructose consumption and TG, SBP, and HDL became non-significant. The results did not show any evidence of publication bias. No missing studies were identified with the trim-and-fill method.
Fructose consumption from industrialized foods has significant effects on most components of metabolic syndrome.
本研究旨在综述现有的人体研究文献，以确定不同剂量和时间的果糖摄入与代谢综合征之间的关联。
我们在 PubMed、Scopus、Ovid、ISI Web of Science、Cochrane 图书馆和 Google Scholar 数据库中搜索人体研究。我们在每篇论文中搜索以下关键词：代谢综合征 x、胰岛素抵抗、血糖、血糖、空腹血糖、甘油三酯、脂蛋白、高密度脂蛋白、胆固醇、低密度脂蛋白、血压、平均动脉压、收缩压、舒张压、高血压、腰围和果糖、蔗糖、高果糖玉米糖浆或糖。
总共收集了 3102 篇文章。我们排除了关于食物中天然果糖含量、非临床试验以及仅推荐果糖作为蔗糖或高果糖玉米糖浆的试验的研究。总共排除了 3069 篇文章。经过独立评审员的审查，有 15 项研究被纳入荟萃分析。果糖摄入与空腹血糖（FBS）升高呈正相关（综合平均差异，0.307；95%置信区间[CI]，0.149-0.465；P=0.002）、甘油三酯（TG）升高（0.275；95%CI，0.014-0.408；P=0.002）和收缩压（SBP）升高（0.297；95%CI，0.144-0.451；P=0.002）。高密度脂蛋白（HDL）胆固醇呈负相关（-0.267；95%CI，-0.406 至-0.128；P=0.001）。除了 FBS 之外，研究之间存在显著的异质性。在排除对异质性检验影响最大的研究后，果糖摄入与 TG、SBP 和 HDL 之间的关联变得不显著。结果没有表明存在发表偏倚的证据。用修剪和填充法没有发现缺失的研究。
工业化食品中的果糖摄入对代谢综合征的大多数成分都有显著影响。
