[A comparison of selective microproteinuria with histomorphology of the kidneys in patients with arterial hypertension].

Urinary excretion of individual proteins has been examined in 30 patients suffering from arterial hypertension, subjected to renal biopsy. The findings indicate an increased excretion of the proteins associated with the localization of the morphologic shifts in the kidneys. Thus, glomerular abnormalities are characterized by a 10-30-fold increase of albumin and IgG excretion with the urine and normal values of beta-2-microglobulin (beta-2-MG); canalicular abnormalities are associated with normal urine albumin or microalbuminuria and 10-40-fold increased excretion of beta-2-MG, paralleled by increased urine N-acetyl-B-glucosaminidase activity, this latter shift indicating grave tubulointerstitial changes. Hypertensive changes of the vessels involve microalbuminuria. Quantitative and qualitative characteristics of proteinuria may become an additional test in the differential diagnosis of symptomatic arterial hypertension.