在诊断为缓慢进展型1型糖尿病时，成人较高的体重指数与较低风险的HLA基因相关。
Higher body mass index in adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus is associated with lower risk HLA genes.
作者信息
Fourlanos S, Elkassaby S, Varney M D, Colman P G, Harrison L C
机构信息
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, VIC; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville 3050, VIC, Australia.
Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, West Melbourne 3003, VIC, Australia.
出版信息
Diabetes Res Clin Pract. 2014 Jun;104(3):e69-71. doi: 10.1016/j.diabres.2014.03.009. Epub 2014 Mar 18.
We hypothesised that higher body weight, a proposed risk factor for type 1 diabetes mellitus, would be associated with increased penetrance of lower risk genes. In adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus we found that higher body mass index was associated with the absence of the highest risk HLA genes.
我们推测，较高体重是1型糖尿病的一个假定风险因素，它可能与低风险基因的更高外显率相关。在被诊断为缓慢进展型1型糖尿病的成年人中，我们发现较高的体重指数与不存在最高风险的HLA基因有关。
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