酮色林的降压作用为何与年龄相关？
Why are the antihypertensive effects of ketanserin age-related?
作者信息
Doyle A E
机构信息
Department of Physiology, University of Melbourne, Parkville, Australia.
出版信息
J Cardiovasc Pharmacol. 1988;12 Suppl 8:S124-31.
PMID:2469894
Abstract
Ketanserin induces larger falls of blood pressure in patients above the age of 60 years, both following acute intravenous and chronic oral administration. Although there is no clear explanation for these findings, it is possible that the age-related effects of ketanserin are due to antagonism of serotonin-induced vasoconstriction occurring in elderly patients with atheroma.
摘要
酮色林无论是在急性静脉给药还是慢性口服给药后，都会使60岁以上患者的血压出现更大幅度的下降。尽管这些发现尚无明确解释，但酮色林与年龄相关的效应可能是由于拮抗了动脉粥样硬化老年患者中5-羟色胺诱导的血管收缩。
Zotero 插件