Xu Dan, Zhao Xin, Li Yi, Ji Yinli, Zhang Jiangyan, Wang Jufang, Xie Xiaodong, Zhou Guangming
Department of Space Radiobiology, Key Laboratory of Heavy Ion Radiation Biology and Medicine, Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, China.
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, 222 Tianshui Road, Lanzhou 730000, China.
J Radiat Res. 2014 Jul;55(4):720-5. doi: 10.1093/jrr/rru014. Epub 2014 Apr 3.
Outer space is a complex environment with various phenomena that negatively affect bone metabolism, including microgravity and highly energized ionizing radiation. In the present study, we used four groups of male Wistar rats treated with or without four-week hindlimb suspension after 4 Gy of X-rays to test whether there is a combined effect for hindlimb suspension and X-ray radiation. We tested trabecular parameters and some cytokines of the bone as leading indicators of bone metabolism. The results showed that hindlimb suspension and X-ray radiation could cause a significant increase in bone loss. Hindlimb suspension caused a 56.6% bone loss (P = 0.036), while X-ray radiation caused a 30.7% (P = 0.041) bone loss when compared with the control group. The combined factors of hindlimb suspension and X-rays exerted a combined effect on bone mass, with a reduction of 64.8% (P = 0.003).
外层空间是一个复杂的环境，存在各种对骨代谢产生负面影响的现象，包括微重力和高能电离辐射。在本研究中，我们使用了四组雄性Wistar大鼠，在接受4 Gy X射线照射后，分别进行或不进行为期四周的后肢悬吊处理，以测试后肢悬吊和X射线辐射是否存在联合效应。我们检测了骨小梁参数和一些骨细胞因子，作为骨代谢的主要指标。结果表明，后肢悬吊和X射线辐射均可导致骨量显著减少。与对照组相比，后肢悬吊导致骨量减少56.6%（P = 0.036），而X射线辐射导致骨量减少30.7%（P = 0.041）。后肢悬吊和X射线的联合因素对骨量产生了联合效应，骨量减少了64.8%（P = 0.003）。
