Rockefeller University, New York, New York, USA.
Department of Microbiology and Immunology, the California Institute of Quantitative Biology and the Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California, USA.
Nat Struct Mol Biol. 2014 Apr;21(4):350-1. doi: 10.1038/nsmb.2798.
Housekeeping σ factors are initiation factors for the bacterial RNA polymerase at most promoters, whereas alternative σs direct focused responses to specific environmental conditions. Structural and functional analysis of an alternative σ complexed with its cognate −10 motif elucidates the mechanism for initiation of strand opening, highlighting two critical properties: why alternative σs, compared to housekeeping σs, recognize so few promoters and how their promoter-recognition strategy was diversified during evolution.
管家 σ 因子是细菌 RNA 聚合酶在大多数启动子上的起始因子，而替代 σ 则指导针对特定环境条件的集中响应。与同源−10 基序复合的替代 σ 复合物的结构和功能分析阐明了链打开起始的机制，突出了两个关键特性：为什么替代 σ 与管家 σ 相比，识别的启动子如此之少，以及它们的启动子识别策略在进化过程中是如何多样化的。
