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脑静脉血栓形成的评估与管理

Evaluation and management of cerebral venous thrombosis.

作者信息

Bushnell Cheryl, Saposnik Gustavo

出版信息

Continuum (Minneap Minn). 2014 Apr;20(2 Cerebrovascular Disease):335-51. doi: 10.1212/01.CON.0000446105.67173.a8.

Abstract

PURPOSE OF REVIEW

Thrombosis of the dural sinus and/or cerebral veins (CVT) is a rare but potentially devastating type of stroke that tends to occur in young adults, especially women. In this article, the abbreviation CVT refers to either cerebral venous thrombosis or dural sinus thrombosis. The purpose of this review is to review the most up-to-date literature on the epidemiology, diagnosis, management, and prognosis of CVT. In addition, illustrative cases that represent the spectrum of CVT are provided.

RECENT FINDINGS

CVT represents about 0.5% of all strokes and can be challenging to diagnose because headache, rather than focal neurologic symptoms, is the prominent feature. The diagnosis is confirmed with MRI and magnetic resonance venogram (MRV). The mainstay of acute management is anticoagulation, although, in the cases of severe hemorrhagic conversion of a venous infarction, endovascular mechanical thrombectomy may be potentially lifesaving. The evaluation of underlying causes from transient triggers, eg, pregnancy, oral contraceptives, or infection, versus chronic triggers, eg, cancer and thrombophilia, will often influence the duration of anticoagulation. The outcomes after CVT are generally favorable, and the risk of recurrence is low.

SUMMARY

CVT is an important diagnosis to keep in mind when evaluating patients with headache in the emergency department, and it is important that it not be overlooked because it is treatable.

摘要

综述目的

硬脑膜窦和/或脑静脉血栓形成(CVT)是一种罕见但可能具有毁灭性的中风类型,多见于年轻人,尤其是女性。在本文中,缩写CVT指脑静脉血栓形成或硬脑膜窦血栓形成。本综述的目的是回顾关于CVT的流行病学、诊断、治疗和预后的最新文献。此外,还提供了代表CVT范围的实例病例。

最新发现

CVT约占所有中风的0.5%,由于突出特征是头痛而非局灶性神经症状,因此诊断可能具有挑战性。通过磁共振成像(MRI)和磁共振静脉造影(MRV)确诊。急性治疗的主要方法是抗凝,不过,在静脉梗死严重出血转化的情况下,血管内机械取栓术可能挽救生命。对潜在病因的评估,从短暂诱因(如妊娠、口服避孕药或感染)与慢性诱因(如癌症和血栓形成倾向),往往会影响抗凝持续时间。CVT后的预后通常良好,复发风险较低。

总结

在急诊科评估头痛患者时,CVT是一个需要牢记的重要诊断,重要的是不要忽视它,因为它是可治疗的。

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