Nardoni A, Di Piazza V, Moretti V, Copetti R, Trinco G
Divisione di Medicina Generale, Ospedale S. Antonio, Tolmezzo (Udine).
Minerva Med. 1989 Mar;80(3):281-3.
5-Hydroxyindoleacetic acid (5-HIAA), the main metabolite of 5-hydroxytryptamine or serotonin, excreted in the urine over a 24 hour period was systematically measured in 35 patients with alcohol withdrawal syndrome (AWS). The level of excreted urinary 5-HIAA ac. was high in only a few patients. The pathogenic mechanisms involved are discussed and though the role of serotonin in the pathogenesis of AWS seems of secondary importance, some 5-hydroxytryptamine methyl analogues may have a major role in the pathogenesis of hallucinations caused by alcohol withdrawal.
5-羟吲哚乙酸（5-HIAA）是5-羟色胺或血清素的主要代谢产物，对35例酒精戒断综合征（AWS）患者在24小时内尿液中排出的5-HIAA进行了系统测量。仅少数患者尿中排出的5-HIAA水平较高。文中讨论了其中涉及的致病机制，虽然血清素在AWS发病机制中的作用似乎次要，但一些5-羟色胺甲基类似物可能在酒精戒断所致幻觉的发病机制中起主要作用。
