Singh Anvesha, Steadman Christopher D, Khan Jamal N, Horsfield Mark A, Bekele Soliana, Nazir Sheraz A, Kanagala Prathap, Masca Nicholas G D, Clarysse Patrick, McCann Gerry P
Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom.
J Magn Reson Imaging. 2015 Apr;41(4):1129-37. doi: 10.1002/jmri.24625. Epub 2014 Apr 3.
To determine the interstudy reproducibility of myocardial strain and peak early-diastolic strain rate (PEDSR) measurement on cardiovascular magnetic resonance imaging (MRI) assessed with feature tracking (FT) and tagging, in patients with aortic stenosis (AS).
Cardiac MRI was performed twice (1-14 days apart) in 18 patients (8 at 1.5 Tesla [T], 10 at 3T) with moderate-severe AS. Circumferential peak systolic strain (PSS) and PEDSR were measured in all patients. Longitudinal PSS and PEDSR were assessed using FT in all patients, and tagging in the 3T sub-group.
PSS was higher with FT than tagging (21.0 ± 1.9% versus 17.0 ± 3.4% at 1.5T, 21.4 ± 4.0% versus 17.7 ± 3.0% at 3T, P < 0.05), as was PEDSR (1.3 ± 0.3 s(-1) versus 1.0 ± 0.3 s(-1) , P = 0.10 at 1.5T and 1.3 ± 0.4 s(-1) versus 0.8 ± 0.3 s(-1) , P < 0.05 at 3T). The reproducibility of PSS was excellent with FT (coefficient of variation [CoV] 9-10%) and good with tagging at 1.5T (13-19%). Reproducibility of circumferential PEDSR was best at 1.5T when only basal/mid slices were included (CoV 12%), but moderate to poor at 3T (29-35%). Reproducibility of longitudinal strain was good with FT (10-16%) but moderate for PEDSR (∼30%).
In patients with AS, FT consistently produces higher values compared with tagging. The interstudy reproducibility of PSS is excellent with FT and good with tagging. The reproducibility of circumferential PEDSR at 1.5T is good when only basal and mid slices are used.
确定在主动脉瓣狭窄(AS)患者中,采用特征跟踪(FT)和标记技术在心血管磁共振成像(MRI)上测量心肌应变和舒张早期峰值应变率(PEDSR)的研究间可重复性。
对18例中重度AS患者(8例在1.5特斯拉[T],10例在3T)进行了两次心脏MRI检查(间隔1 - 14天)。测量所有患者的圆周峰值收缩期应变(PSS)和PEDSR。对所有患者使用FT评估纵向PSS和PEDSR,对3T亚组使用标记技术。
FT测量的PSS高于标记技术(1.5T时分别为21.0±1.9%对17.0±3.4%,3T时分别为21.4±4.0%对17.7±3.0%,P<0.05),PEDSR也是如此(1.5T时分别为1.3±0.3 s⁻¹对1.0±0.3 s⁻¹,P = 0.10;3T时分别为1.3±0.4 s⁻¹对0.8±0.3 s⁻¹,P<0.05)。FT测量PSS的可重复性极佳(变异系数[CoV]为9 - 10%),1.5T时标记技术的可重复性良好(13 - 19%)。仅纳入基底/中层切片时,1.5T时圆周PEDSR的可重复性最佳(CoV为12%),但3T时为中度至较差(29 - 35%)。纵向应变采用FT时可重复性良好(10 - 16%),但PEDSR的可重复性为中度(约30%)。
在AS患者中,与标记技术相比,FT始终产生更高的值。PSS的研究间可重复性采用FT时极佳,采用标记技术时良好。仅使用基底和中层切片时,1.5T时圆周PEDSR的可重复性良好。