Makino K, Ohshima H, Kondo T
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Pharm Res. 1987 Feb;4(1):62-5. doi: 10.1023/a:1016438129284.
The degradation rate of poly(L-lactide) microcapsules in an aqueous medium was accelerated by the addition of albumin, gamma-globulins, and fibrinogen. These proteins form adsorption layers on the surface of poly(L-lactide) microcapsules. At the interface between the microcapsules and the adsorbed protein layers, the value of the electric potential is expected to increase in magnitude, i.e., become highly negative compared with that at the interface between the microcapsules and the bulk buffer solution containing no plasma protein. This potential increase causes an increase in H+ concentration at that interface, which may result in an acceleration of the hydrolytic degradation rate of poly(L-lactide) microcapsules. Also, the presence of plasma proteins can increase the solubility of poly(L-lactide), causing the poly(L-lactide) molecules to exist in an expanded form. This effect may also accelerate the degradation of poly(L-lactide) microcapsules.
通过添加白蛋白、γ-球蛋白和纤维蛋白原，聚（L-丙交酯）微胶囊在水性介质中的降解速率加快。这些蛋白质在聚（L-丙交酯）微胶囊表面形成吸附层。在微胶囊与吸附蛋白层之间的界面处，电势值预计会增大，即与微胶囊和不含血浆蛋白的本体缓冲溶液之间的界面相比，变得高度负性。这种电势增加会导致该界面处H⁺浓度升高，这可能导致聚（L-丙交酯）微胶囊的水解降解速率加快。此外，血浆蛋白的存在会增加聚（L-丙交酯）的溶解度，使聚（L-丙交酯）分子以膨胀形式存在。这种效应也可能加速聚（L-丙交酯）微胶囊的降解。
