Makino K, Ohshima H, Kondo T
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
J Microencapsul. 1990 Apr-Jun;7(2):199-208. doi: 10.3109/02652049009021833.
A model is presented for the potential distribution across a protein-coated microcapsule membrane. The adsorbed protein layer is assumed to be divided into three sub-layers. The outer sub-layer is rich in positive fixed charges and the medium sub-layer in negative fixed charges, while the inner sub-layer may be either charged or uncharged. Also, the microcapsule membrane is negatively charged. The ionic partition coefficients into the inner sub-layer are less than unity, while those into the other sub-layers are unity. This model explains well the accelerated degradation of poly(L-lactide) microcapsules with an adsorbed protein layer onto their surface (Makino et al., 1987 c).
提出了一种用于描述蛋白质包被微胶囊膜上电位分布的模型。假定吸附的蛋白质层分为三个子层。外层富含正固定电荷，中层富含负固定电荷，而内层可能带电也可能不带电。此外，微胶囊膜带负电。离子向内层的分配系数小于1，而向其他子层的分配系数为1。该模型很好地解释了表面吸附有蛋白质层的聚（L-丙交酯）微胶囊加速降解的现象（牧木等人，1987年c）。
