Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Clin J Am Soc Nephrol. 2014 Jun 6;9(6):1138-40. doi: 10.2215/CJN.01450214. Epub 2014 Apr 3.
The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue asked the scientific community to formulate and prioritize research objectives aimed at improved understanding of kidney function and disease progression. Over the past 2 years, 1600 participants posted almost 300 ideas covering all areas of kidney disease. An overriding theme that evolved through these discussions is the need to move beyond pathology to take advantage of basic science and clinical research opportunities to improve diagnostic classification and therapeutic options for people with primary glomerular disease. High-priority research areas included focus on therapeutic targets in glomerular endothelium and podocytes, regenerating podocytes through developmental pathways, use of longitudinal phenotypically defined disease cohorts to improve classification schemes, identifying biomarkers, disease-specific therapeutics, autoantibody triggers, and changing the clinical research culture to promote participation in clinical trials. Together, these objectives provide a path forward for improving clinical outcomes of glomerular disease.
美国国家糖尿病、消化和肾脏疾病研究所支持的肾脏研究国家对话要求科学界制定并优先考虑研究目标，旨在增进对肾脏功能和疾病进展的理解。在过去的 2 年中，1600 名参与者提出了近 300 条涵盖肾脏疾病各个领域的想法。通过这些讨论形成的一个首要主题是，需要超越病理学，利用基础科学和临床研究机会，改善原发性肾小球疾病患者的诊断分类和治疗选择。优先研究领域包括关注肾小球内皮细胞和足细胞的治疗靶点、通过发育途径再生足细胞、利用纵向表型定义的疾病队列来改善分类方案、确定生物标志物、疾病特异性治疗、自身抗体触发因素，以及改变临床研究文化以促进参与临床试验。这些目标共同为改善肾小球疾病的临床结果提供了前进的道路。
