Bose Anushree, Agarwal Sri Mahavir, Kalmady Sunil V, Venkatasubramanian Ganesan
Department of Psychiatry, The Schizophrenia Clinic, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India ; Department of Psychiatry, Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Indian J Psychol Med. 2014 Jan;36(1):9-26. doi: 10.4103/0253-7176.127242.
Hippocampal deficits are an established feature of schizophrenia and are complementary with recent evidences of marked allocentric processing deficits being reported in this disorder. By "Cognitive mapping" we intend to refer to the concepts from the seminal works of O'Keefe and Nadel (1978) that led to the development of cognitive map theory of hippocampal function. In this review, we summarize emerging evidences and issues that indicate that "Cognitive mapping deficits" form one of the important cognitive aberrations in schizophrenia. The importance has been placed upon hippocampally mediated allocentric processing deficits and their role in pathology of schizophrenia, for spatial/representational cognitive deficits and positive symptoms in particular. It is modestly summarized that emerging evidences point toward a web of spatial and cognitive representation errors concurrent with pronounced hippocampal dysfunction. In general, it can be stated that there are clear and consistent evidences that favor the cognitive mapping theory in explaining certain deficits of schizophrenia and for drawing out a possible and promising endophenotype/biomarkers. Further research in this regard demands attention.
海马体功能缺陷是精神分裂症的一个既定特征，并且与该疾病中近期报道的明显的以自我为中心的加工缺陷的证据相辅相成。通过“认知地图”，我们旨在提及奥基夫和纳德尔（1978年）开创性著作中的概念，这些概念促成了海马体功能认知地图理论的发展。在本综述中，我们总结了新出现的证据和问题，这些证据和问题表明“认知地图缺陷”是精神分裂症重要的认知畸变之一。重点在于海马体介导的以自我为中心的加工缺陷及其在精神分裂症病理学中的作用，特别是对于空间/表征认知缺陷和阳性症状。简要总结如下，新出现的证据指向与明显的海马体功能障碍同时存在的一系列空间和认知表征错误。一般来说，可以说有明确且一致的证据支持认知地图理论来解释精神分裂症的某些缺陷，并得出一种可能且有前景的内表型/生物标志物。这方面的进一步研究需要关注。
