Asking B, Proctor G B
Institute of Physiology and Biophysics, Lund, Sweden.
Q J Exp Physiol. 1989 Jan;74(1):45-52. doi: 10.1113/expphysiol.1989.sp003238.
Observations were made on amylase secretion from the rat parotid gland induced by parasympathetic nerve stimulation in vivo. In spite of a low salivary amylase concentration a large total amylase output, equivalent to 36% of initial gland content, was found on prolonged activation (5 Hz, 120 min). However, no decrease in gland amylase content was found, which indicates that the output of amylase was balanced by synthesis. We suggest that prolonged, parasympathetically induced amylase secretion is dependent on activation of amylase synthesis and that the secretion is mainly of non-granular origin. Parasympathetic nerve stimulation produced an even larger amylase output from sympathectomized glands. Even under these conditions gland amylase content was unchanged and no obvious degranulation was found when the glands were examined after stimulation. This is in marked contrast to the decrease in amylase content and to the degranulation which are found after sympathetic activation.
对体内副交感神经刺激诱导的大鼠腮腺淀粉酶分泌进行了观察。尽管唾液淀粉酶浓度较低，但在长时间激活（5赫兹，120分钟）时，发现总淀粉酶输出量很大，相当于初始腺体含量的36%。然而，未发现腺体淀粉酶含量降低，这表明淀粉酶的输出通过合成得以平衡。我们认为，副交感神经诱导的长时间淀粉酶分泌依赖于淀粉酶合成的激活，且该分泌主要源自非颗粒性物质。副交感神经刺激使去交感神经支配的腺体产生更大的淀粉酶输出量。即使在这些条件下，腺体淀粉酶含量仍未改变，刺激后检查腺体时也未发现明显的脱颗粒现象。这与交感神经激活后发现的淀粉酶含量降低和脱颗粒现象形成了显著对比。
