Asking B
Acta Physiol Scand. 1985 Aug;124(4):535-42. doi: 10.1111/j.1748-1716.1985.tb00045.x.
The amylase secretion in vivo was examined in the rat parotid gland. A comparison was made between individual stimulation of sympathetic and parasympathetic nerves and simultaneous activation of both nerves. When sympathetic stimulation was superimposed on a parasympathetic background activity, amylase secretion was elicited at a frequency far below the threshold for secretion of fluid, and increased in a frequency-dependent way. This augmented amylase secretion, seen when the two nerves were activated at the same time, gave an amylase output which far exceeded the sum obtained at individual nerve stimulation. The sympathetic amylase secretion obtained in a background of parasympathetic activity seemed to be dependent entirely on beta 1-adrenoceptors. When high sympathetic stimulation frequency (3-10 Hz) was used a reduction in salivary flow was seen, which was accompanied by a reduced amylase output. This effect was counteracted by alpha-adrenoceptor blockade. Isoprenaline, injected intravenously during an ongoing parasympathetic activity, was found to evoke an augmented amylase secretion in a similar way as sympathetic nerve stimulation.
在大鼠腮腺中检测了体内淀粉酶的分泌情况。对交感神经和副交感神经的单独刺激以及两者神经的同时激活进行了比较。当交感神经刺激叠加在副交感神经背景活动上时，淀粉酶分泌以远低于液体分泌阈值的频率引发，并以频率依赖性方式增加。当两条神经同时激活时出现的这种增强的淀粉酶分泌，其淀粉酶输出远远超过单独神经刺激时获得的总和。在副交感神经活动背景下获得的交感神经淀粉酶分泌似乎完全依赖于β1-肾上腺素能受体。当使用高交感神经刺激频率（3-10赫兹）时，唾液流量减少，同时淀粉酶输出也减少。这种效应可被α-肾上腺素能受体阻断所抵消。发现在持续的副交感神经活动期间静脉注射异丙肾上腺素，会以与交感神经刺激类似的方式引发增强的淀粉酶分泌。
