Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Evid Based Complement Alternat Med. 2014;2014:890950. doi: 10.1155/2014/890950. Epub 2014 Feb 20.
Aspirin resistance (AR) is a prevalent phenomenon and leads to significant clinical consequences, but the current evidence for effective interventional strategy is insufficient. The objective of this systematic review is thus to assess the efficacy and safety of Chinese herbal medicine (CHM) for AR. A systematical literature search was conducted in 6 databases until December 2012 to identify randomized controlled trials (RCTs) of CHM for AR. As a result, sixteen RCTs with a total of 1011 subjects were identified, suggesting that the interests of the medical profession and the public in the use of CHM for AR have grown considerably in the recent years. Tongxinluo capsule and Danshen-based prescriptions were the most frequently used herbal prescriptions, while danshen root, milkvetch root, Leech, and Rosewood were the most frequently used single herbs. Despite the apparent reported positive findings, it is premature to determine the efficacy and safety of CHM for the treatment of AR due to poor methodological quality and insufficient safety data. However, CHMs appeared to be well tolerated in all included studies. Thus, CHM as a promising candidate is worthy of improvement and development for further clinical AR trials. Large sample-size and well-designed rigorous RCTs are needed.
阿司匹林抵抗（AR）是一种普遍存在的现象，会导致严重的临床后果，但目前有效的干预策略证据不足。因此，本系统评价旨在评估中药（CHM）治疗 AR 的疗效和安全性。系统检索了 6 个数据库，直到 2012 年 12 月，以确定用于 AR 的 CHM 的随机对照试验（RCT）。结果，确定了 16 项 RCT，共 1011 例受试者，表明近年来医疗行业和公众对 CHM 治疗 AR 的兴趣显著增加。通心络胶囊和丹参类方剂是最常用的草药方剂，而丹参、黄芪、水蛭和紫檀是最常用的单味药。尽管明显报告了阳性结果，但由于方法学质量差和安全性数据不足，尚不能确定 CHM 治疗 AR 的疗效和安全性。然而，在所有纳入的研究中，CHM 似乎均耐受良好。因此，CHM 作为一种有前途的候选药物，值得进一步改善和开发，以进行进一步的临床 AR 试验。需要进行大样本量和精心设计的严格 RCT。
