Gahalaut Pratik, Mishra Nitin, Chauhan Sandhya, Ali Mir Mubashir, Rastogi Madhur Kant, Thakur Richa
Department of Dermatology, SRMSIMS, Bareilly, Uttar Pradesh 243001, India.
Department of Pediatrics, SRMSIMS, Bareilly, Uttar Pradesh 243001, India.
ISRN Dermatol. 2014 Feb 23;2014:271230. doi: 10.1155/2014/271230. eCollection 2014.
Lunula is the white, half-moon shaped area seen in proximal ends of some nails. Though a few studies have described the nail changes that can occur in association with HIV infection, none of these paid much attention to lunula. Aims and Objectives. To study the lunula in fingernails among HIV infected patients. Materials and Methods. An observational, cross-sectional study to record presence of lunula in 168 HIV-positive patients and compare it with age and sex matched 168 healthy HIV-negative control. Anolunula (absence of lunula) in HIV-positive patients was correlated with CD4 counts, stages of HIV infection, time since patient was diagnosed as HIV-positive, and status of antiretroviral therapy. Results. Anolunula was present in significantly more fingernails in HIV-positive patients compared to HIV-negative controls. There was a highly significant difference for total anolunula (anolunula in all fingernails) in study and control group. Incidence of total anolunula was directly proportional to the stage of HIV infection, increasing progressively as the HIV infection advances from stage 1 to stage 4. Conclusion. Absence of lunula is related to not only HIV infection per se but also the stages of HIV infection.
甲半月是在某些指甲近端可见的白色半月形区域。尽管有一些研究描述了与HIV感染相关的指甲变化，但这些研究都没有太多关注甲半月。目的。研究HIV感染患者指甲中的甲半月。材料与方法。一项观察性横断面研究，记录168例HIV阳性患者甲半月的存在情况，并将其与年龄和性别匹配的168例健康HIV阴性对照者进行比较。HIV阳性患者的无甲半月（甲半月缺失）与CD4细胞计数、HIV感染阶段、患者被诊断为HIV阳性后的时间以及抗逆转录病毒治疗状态相关。结果。与HIV阴性对照相比，HIV阳性患者指甲中无甲半月的情况明显更多。研究组和对照组的总无甲半月（所有指甲均无甲半月）存在高度显著差异。总无甲半月的发生率与HIV感染阶段成正比，随着HIV感染从1期进展到4期而逐渐增加。结论。甲半月缺失不仅与HIV感染本身有关，还与HIV感染阶段有关。
