二甲苯的健康危害：文献综述
Health hazards of xylene: a literature review.
作者信息
T Rajan Sharada, Malathi N
机构信息
Senior lecturer, Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra University , Chennai, India .
Professor and Head, Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra University , Chennai, India .
出版信息
J Clin Diagn Res. 2014 Feb;8(2):271-4. doi: 10.7860/JCDR/2014/7544.4079. Epub 2014 Feb 3.
Abstract
Xylene, an aromatic hydrocarbon is widely used in industry and medical laboratory as a solvent. It is a flammable liquid that requires utmost care during its usage. On exposure the vapours are rapidly absorbed through the lungs and the slowly through the skin. Prolonged exposure to xylene leads to significant amount of solvent accumulation in the adipose and muscle tissue. This article reviews the various acute and chronic health effects of xylene through various routes of exposure.
摘要
二甲苯是一种芳香烃，在工业和医学实验室中被广泛用作溶剂。它是一种易燃液体，使用过程中需要格外小心。接触时，其蒸气会迅速通过肺部被吸收，也会缓慢通过皮肤被吸收。长期接触二甲苯会导致大量溶剂在脂肪和肌肉组织中蓄积。本文综述了二甲苯通过各种接触途径产生的各种急性和慢性健康影响。
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Health hazards of xylene: a literature review.二甲苯的健康危害：文献综述
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本文引用的文献
1
A novel non-toxic xylene substitute (SBO) for histology.一种用于组织学的新型无毒二甲苯替代物（SBO）。
Afr J Tradit Complement Altern Med. 2011 Oct 2;9(1):43-9. doi: 10.4314/ajtcam.v9i1.6. eCollection 2012.
2
Mineral oil--a biofriendly substitute for xylene in deparaffinization: a novel method.矿物油——用于脱石蜡过程中替代二甲苯的生物友好型替代品：一种新方法。
J Contemp Dent Pract. 2013 Mar 1;14(2):281-6. doi: 10.5005/jp-journals-10024-1314.
3
Conventional xylene and xylene-free methods for routine histopathological preparation of tissue sections.用于组织切片常规组织病理学制备的传统二甲苯法和无二甲苯法。
Biotech Histochem. 2013 Jul;88(5):235-41. doi: 10.3109/10520295.2013.764015. Epub 2013 Feb 4.
4
A study to evaluate the efficacy of xylene-free hematoxylin and eosin staining procedure as compared to the conventional hematoxylin and eosin staining: An experimental study.一项评估与传统苏木精和伊红染色相比的无二甲苯苏木精和伊红染色程序疗效的研究：一项实验研究。
J Oral Maxillofac Pathol. 2011 May;15(2):161-7. doi: 10.4103/0973-029X.84482.
5
[Complete elimination of xylene in practice of a histology laboratory].[组织学实验室实践中二甲苯的完全消除]
Arkh Patol. 2011 Jan-Feb;73(1):54-60.
6
Xylene: An overview of its health hazards and preventive measures.二甲苯：其健康危害及预防措施概述
J Oral Maxillofac Pathol. 2010 Jan;14(1):1-5. doi: 10.4103/0973-029X.64299.
7
Histology without xylene.无需二甲苯的组织学
Ann Diagn Pathol. 2009 Aug;13(4):246-56. doi: 10.1016/j.anndiagpath.2008.12.005. Epub 2009 Feb 5.
8
Validation of an HPLC-MS/MS method for the simultaneous determination of phenylmercapturic acid, benzylmercapturic acid and o-methylbenzyl mercapturic acid in urine as biomarkers of exposure to benzene, toluene and xylenes.用于同时测定尿液中苯巯基尿酸、苄基巯基尿酸和邻甲基苄基巯基尿酸作为苯、甲苯和二甲苯暴露生物标志物的高效液相色谱-串联质谱法的验证。
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):115-22. doi: 10.1016/j.jchromb.2008.01.022. Epub 2008 Jan 18.
9
Percutaneous penetration via hand eczema is the major accelerating factor for systemic absorption of toluene and xylene during car spray painting.
Contact Dermatitis. 2008 Feb;58(2):76-9. doi: 10.1111/j.1600-0536.2007.01265.x.
10
Delayed and competitively inhibited excretion of urinary hippuric acid in field workers coexposed to toluene, ethyl benzene, and xylene.同时接触甲苯、乙苯和二甲苯的野外工作者尿马尿酸排泄延迟且受到竞争性抑制。
Arch Environ Contam Toxicol. 2007 Nov;53(4):678-83. doi: 10.1007/s00244-006-0084-5. Epub 2007 Jun 14.
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