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脊髓、吸入和全静脉麻醉技术对膝关节镜手术中缺血再灌注损伤的影响。

The effects of spinal, inhalation, and total intravenous anesthetic techniques on ischemia-reperfusion injury in arthroscopic knee surgery.

作者信息

Koşucu Müge, Coşkun Ilker, Eroglu Ahmet, Kutanis Dilek, Menteşe Ahmet, Karahan S Caner, Baki Emre, Kerimoğlu Servet, Topbas Murat

机构信息

Department of Anesthesiology, KTU Farabi Hospital, Medical School of Karadeniz Technical University, 61080 Trabzon, Turkey.

Department of Biochemistry, Medical School of Karadeniz Technical University, 61080 Trabzon, Turkey.

出版信息

Biomed Res Int. 2014;2014:846570. doi: 10.1155/2014/846570. Epub 2014 Feb 20.

DOI:10.1155/2014/846570
PMID:24701585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3950662/
Abstract

PURPOSE

To compare the effects of different anesthesia techniques on tourniquet-related ischemia-reperfusion by measuring the levels of malondialdehyde (MDA), ischemia-modified albumin (IMA) and neuromuscular side effects.

METHODS

Sixty ASAI-II patients undergoing arthroscopic knee surgery were randomised to three groups. In Group S, intrathecal anesthesia was administered using levobupivacaine. Anesthesia was induced and maintained with sevoflurane in Group I and TIVA with propofol in Group T. Blood samples were obtained before the induction of anesthesia (t1), 30 min after tourniquet inflation (t2), immediately before (t3), and 5 min (t4), 15 min (t5), 30 min (t 6), 1 h (t7), 2 h (t8), and 6 h (t9) after tourniquet release.

RESULTS

MDA and IMA levels increased significantly compared with baseline values in Group S at t2-t 9 and t2-t7. MDA levels in Group T and Group I were significantly lower than those in Group S at t2-t8 and t2-t9. IMA levels in Group T were significantly lower than those in Group S at t2-t7. Postoperatively, a temporary 1/5 loss of strength in dorsiflexion of the ankle was observed in 3 patients in Group S and 1 in Group I.

CONCLUSIONS

TIVA with propofol can make a positive contribution in tourniquet-related ischemia-reperfusion.

摘要

目的

通过测量丙二醛（MDA）、缺血修饰白蛋白（IMA）水平及神经肌肉副作用，比较不同麻醉技术对止血带相关缺血再灌注的影响。

方法

60例拟行膝关节镜手术的ASA I-II级患者随机分为三组。S组采用左旋布比卡因行蛛网膜下腔麻醉。I组采用七氟醚诱导和维持麻醉，T组采用丙泊酚全凭静脉麻醉。于麻醉诱导前（t1）、止血带充气后30分钟（t2）、止血带松开前即刻（t3）以及止血带松开后5分钟（t4）、15分钟（t5）、30分钟（t6）、1小时（t7）、2小时（t8）和6小时（t9）采集血样。

结果

S组在t2-t9和t2-t7时MDA和IMA水平较基线值显著升高。T组和I组在t2-t8和t2-t9时MDA水平显著低于S组。T组在t2-t7时IMA水平显著低于S组。术后，S组有3例患者、I组有1例患者出现踝关节背屈肌力暂时减弱1/5。

结论

丙泊酚全凭静脉麻醉对止血带相关缺血再灌注有积极作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef64/3950662/b138d689974d/BMRI2014-846570.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef64/3950662/347a7c2f1765/BMRI2014-846570.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef64/3950662/b138d689974d/BMRI2014-846570.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef64/3950662/347a7c2f1765/BMRI2014-846570.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef64/3950662/b138d689974d/BMRI2014-846570.002.jpg

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3
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