Turner D, Luzio S, Kilduff L P, Gray B J, Dunseath G, Bain S C, Campbell M D, West D J, Bracken R M
Applied Sports, Technology, Exercise and Medicine Research Centre, College of Engineering, Swansea University, Singleton Park, Swansea, UK; Diabetes Research Group, College of Medicine, Swansea University, Singleton Park, Swansea, UK.
Diabet Med. 2014 Aug;31(8):1009-13. doi: 10.1111/dme.12462. Epub 2014 Apr 25.
To determine the influence of different volumes of resistance exercise on circulating interleukin-6 (IL-6) and to explore the relationships between IL-6 and glycaemia.
Eight participants with complication-free type 1 diabetes, whose mean ± SEM age was 38 (6) years, mean ± SEM HbA(1c) concentration was 71 ±11 mmol/mol (8.7 ±1.0%) and mean ± SEM type 1 diabetes duration was 15 ±13 years, attended the research facility after an overnight fast on four separate occasions, having administered their basal insulin the night before (glargine 27.5±3.1U, n=8), but omitted morning rapid-acting insulin. Participants completed either a one-set (14-min), two-set (28-min), or three-set (42-min) resistance exercise trial (eight exercises × 10 repetitions) at 67±3% one-repetition maximum followed by a 60-min recovery, or a resting control trial. Venous blood samples were taken before and after exercise. Data were analysed using repeated-measures ANOVA (P≤0.05).
Whereas IL-6 levels remained similar to baseline levels after one set of resistance exercises (30 min, P=0.287; 60 min, P=0.318), IL-6 levels were > baseline levels at 60 min post-exercise after a two-set exercise trial (2.94 ± 0.94 pg/ml, P=0.002) and doubled at both 30 min (4.01 ± 1.00 pg/ml, P=0.048) and 60 min (4.28 ± 1.25 pg/ml, P=0.084) post-exercise after the three-set resistance exercise trial. Post-exercise blood glucose area under the curve (mmol/l/60 min) was greater after both the one-set (P=0.025) and two-set trials (P=0.008), than after the control trial, but similar between the three-set trial and the control trial (P=0.240). The rise in IL-6 from baseline to peak concentration significantly correlated inversely with blood glucose area under the curve (r=-0.65, P=0.041).
Circulating IL-6 is increased by resistance exercise in a volume-dependent manner, and resistance exercise-induced increases in IL-6 correlated with reductions in post-exercise hyperglycaemia in type 1 diabetes, suggesting a role for IL-6 in improving post-resistance exercise glycaemic disturbances in type 1 diabetes.
确定不同运动量的抗阻运动对循环白细胞介素-6（IL-6）的影响，并探讨IL-6与血糖之间的关系。
8名无并发症的1型糖尿病患者，其平均年龄±标准误为38（6）岁，平均HbA（1c）浓度±标准误为71±11 mmol/mol（8.7±1.0%），1型糖尿病病程平均±标准误为15±13年。在四个不同的日子里，他们在禁食过夜后到研究机构，前一晚已注射基础胰岛素（甘精胰岛素27.5±3.1U，n = 8），但省略了早晨的速效胰岛素。参与者完成了一组（14分钟）、两组（28分钟）或三组（42分钟）的抗阻运动试验（八项运动×10次重复），运动强度为一次重复最大值的67±3%，随后进行60分钟的恢复，或进行静息对照试验。在运动前后采集静脉血样。数据采用重复测量方差分析进行分析（P≤0.05）。
一组抗阻运动后（30分钟，P = 0.287；60分钟，P = 0.318），IL-6水平与基线水平相似，而两组运动试验后运动后60分钟IL-6水平高于基线水平（2.94±0.94 pg/ml，P = 0.002），三组抗阻运动试验后运动后30分钟（4.01±1.00 pg/ml，P = 0.048）和60分钟（4.28±1.25 pg/ml，P = 0.084）时IL-6水平翻倍。一组（P = 0.025）和两组试验后（P = 0.008）运动后血糖曲线下面积（mmol/l/60分钟）均大于对照试验，但三组试验与对照试验之间相似（P = 0.240）。IL-6从基线到峰值浓度的升高与血糖曲线下面积显著负相关（r = -0.65，P = 0.041）。
抗阻运动以运动量依赖的方式增加循环IL-6，且抗阻运动诱导的IL-6增加与1型糖尿病运动后高血糖的降低相关，提示IL-6在改善1型糖尿病抗阻运动后血糖紊乱中发挥作用。
