免疫球蛋白G在IgE介导的过敏及过敏原特异性免疫治疗中的作用
Immunoglobulin G in IgE-mediated allergy and allergen-specific immunotherapy.
作者信息
Hofmaier S, Comberiati P, Matricardi P M
机构信息
Department of Pediatric Pneumology and Immunology, Charitá Medical School, Berlin, Germany.
Department of Pediatrics, University of Verona, G.B. Rossi Polyclinic, Verona, Italy.
出版信息
Eur Ann Allergy Clin Immunol. 2014 Jan;46(1):6-11.
Allergen-specific IgG antibodies play a significant role in allergen-specific tolerance, either naturally induced or generated by specific immunotherapy. Nevertheless, the underlying mechanisms are still debated, and allergen-specific IgG determinations are not recommended as a diagnostic tool in IgE-mediated allergy. This review summarizes the latest findings on the immunological and diagnostic role of IgG antibodies in respiratory and food allergies, and during allergen-specific immunotherapy.
过敏原特异性IgG抗体在自然诱导或特异性免疫疗法产生的过敏原特异性耐受中发挥着重要作用。然而，其潜在机制仍存在争议，且不建议将过敏原特异性IgG检测作为IgE介导的过敏症的诊断工具。本文综述了IgG抗体在呼吸道和食物过敏以及过敏原特异性免疫疗法中的免疫和诊断作用的最新研究结果。
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