Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain.
Immunotherapy. 2013 Jul;5(7):755-68. doi: 10.2217/imt.13.63.
Food allergy is an increasing problem in western countries, with strict avoidance being the only available reliable treatment. However, accidental ingestion can occur and anaphylactic reactions still happen. In recent years, many efforts have been made to better understand the humoral and cellular mechanisms involved in food allergy, and to improve the strategies for diagnosis and treatment. This review focuses on IgE-mediated food hypersensitivity and provides an overview of the diagnostic strategies and treatment advances. Specific immunotherapy, including different routes of administration and allergen sources, such as natural, recombinant and T-cell epitopes, are analyzed in detail. Other treatments such as anti-IgE monoclonal antibody therapy, adjuvant therapy and Chinese herbs will also be described.
食物过敏是西方国家日益严重的问题，严格避免食用是唯一可靠的治疗方法。然而，仍会发生意外摄入和过敏反应。近年来，人们做出了许多努力来更好地了解食物过敏所涉及的体液和细胞机制，并改善诊断和治疗策略。本综述重点关注 IgE 介导的食物过敏，并概述了诊断策略和治疗进展。详细分析了特异性免疫治疗，包括不同的给药途径和过敏原来源，如天然、重组和 T 细胞表位。还描述了其他治疗方法，如抗 IgE 单克隆抗体治疗、佐剂治疗和中药。
