Rothenberg Ellen V
Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125 USA.
Trends Immunol. 2014 May;35(5):195-204. doi: 10.1016/j.it.2014.03.001. Epub 2014 Apr 2.
T cell development from multipotent progenitors to specialized effector subsets of mature T cells is guided by the iterative action of transcription factors. At each stage, transcription factors interact not only with an existing landscape of histone modifications and nucleosome packing, but also with other bound factors, while they modify the landscape for later-arriving factors in ways that fundamentally affect the control of gene expression. This review covers insights from genome-wide analyses of transcription factor binding and resulting chromatin conformation changes that reveal roles of cytokine signaling in effector T cell programming, the ways in which one factor can completely transform the impacts of previously bound factors, and the ways in which the baseline chromatin landscape is established during early T cell lineage commitment.
从多能祖细胞到成熟T细胞的特异性效应子亚群的T细胞发育由转录因子的迭代作用引导。在每个阶段，转录因子不仅与现有的组蛋白修饰和核小体包装格局相互作用，还与其他结合因子相互作用，同时它们以从根本上影响基因表达控制的方式改变格局，为后来到达的因子创造条件。本综述涵盖了转录因子结合的全基因组分析以及由此产生的染色质构象变化的见解，这些见解揭示了细胞因子信号在效应T细胞编程中的作用、一种因子能够完全改变先前结合因子影响的方式，以及在早期T细胞谱系定向过程中建立基线染色质格局的方式。
