新陈代谢迅速传播。
Metabolism goes viral.
作者信息
Miyake-Stoner Shigeki J, O'Shea Clodagh C
机构信息
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA.
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA.
出版信息
Cell Metab. 2014 Apr 1;19(4):549-50. doi: 10.1016/j.cmet.2014.03.022.
Abstract
Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides for viral replication.
摘要
病毒癌基因和细胞癌基因在靶向关键蛋白质相互作用网络方面具有趋同性，从而重新编程细胞的DNA和蛋白质复制机制以进行病理性复制。在本期中，泰等人（2014年）表明腺病毒E4ORF1激活MYC糖酵解靶点，以诱导一种类似瓦伯格效应，将葡萄糖转化为核苷酸用于病毒复制。
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